ArticlePloS one2012
Comprehensive mutation analysis in colorectal flat adenomas.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Signal transduction pathway mutations in gastrointestinal (GI) cancers: a systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Mutational landscape in the precancerous stages of sporadic colorectal cancer.Oncology letters · 2026Article
- The Molecular Landscape of Colorectal Laterally Spreading Tumors: From Endoscopic Subtypes to Molecular Targets.International journal of molecular sciences · 2025Review
- Article
- Molecular pathways in post-colonoscopy versus detected colorectal cancers: results from a nested case-control study.British journal of cancer · 2022Article
- Mutational analysis of driver genes defines the colorectal adenoma: in situ carcinoma transition.Scientific reports · 2022Article
- The Genomic Landscape of Serrated Lesion of the Colorectum: Similarities and Differences With Tubular and Tubulovillous Adenomas.Frontiers in oncology · 2021Article
- Multitarget Stool DNA Test Performance in an Average-Risk Colorectal Cancer Screening Population.The American journal of gastroenterology · 2019Article
- Genetic Aberration Analysis in Thai Colorectal Adenoma and Early-Stage Adenocarcinoma Patients by Whole-Exome Sequencing.Cancers · 2019Article
- Low-grade slightly elevated and polypoid colorectal adenomas display differential β-catenin-TCF/LEF activity, c-Myc, and cyclin D1 expression.World journal of gastroenterology · 2017Article
- Whole-exome sequencing identified mutational profiles of high-grade colon adenomas.Oncotarget · 2017Article
- Exome sequencing identifies potential novel candidate genes in patients with unexplained colorectal adenomatous polyposis.Familial cancer · 2016Article
- Distinct molecular features of different macroscopic subtypes of colorectal neoplasms.PloS one · 2014Article
- Promoter methylation of Wnt-antagonists in polypoid and nonpolypoid colorectal adenomas.BMC cancer · 2013Article
- [Precancerous colorectal tumors].Der Internist · 2013Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFlat adenomas are a subgroup of colorectal adenomas that have been associated with a distinct biology and a more aggressive clinical behavior compared to their polypoid counterparts. In the present study, we aimed to compare the mutation spectrum of 14 cancer genes, between these two phenotypes.
methodsA consecutive series of 106 flat and 93 polypoid adenomas was analyzed retrospectively for frequently occurring mutations in "hot spot" regions of KRAS, BRAF, PIK3CA and NRAS, as well as selected mutations in CTNNB1 (β-catenin), EGFR, FBXW7 (CDC4), PTEN, STK11, MAP2K4, SMAD4, PIK3R1 and PDGFRA using a high-throughput genotyping technique. Additionally, APC was analyzed using direct sequencing.
resultsAPC mutations were more frequent in polypoid adenomas compared to flat adenomas (48.5% versus 30.3%, respectively, p = 0.02). Mutations in KRAS, BRAF, NRAS, FBXW7 and CTNNB1 showed similar frequencies in both phenotypes. Between the different subtypes of flat adenomas (0-IIa, LST-F and LST-G) no differences were observed for any of the investigated genes.
conclusionThe lower APC mutation rate in flat adenomas compared to polypoid adenomas suggests that disruption of the Wnt-pathway may occur via different mechanisms in these two phenotypes. Furthermore, in contrast to previous observations our results in this large well-defined sample set indicate that there is no significant association between the different morphological phenotypes and mutations in key genes of the RAS-RAF-MAPK pathway.
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