ArticlePloS one2012
IL-21 regulates the differentiation of a human γδ T cell subset equipped with B cell helper activity.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 56 citations in OpenAlex.
- Polarization of Vδ2 T cells to a Th2-like phenotype promotes plasmablast differentiation and possesses pro-fibrotic properties in IgG4-related disease.Frontiers in immunology · 2025Article
- The role of γδT lymphocytes in atherosclerosis.Frontiers in immunology · 2024Review
- Tumor-infiltrating lymphocytes in the immunotherapy era.Cellular & molecular immunology · 2021Review
- Decidual RANKL/RANK interaction promotes the residence and polarization of TGF-β1-producing regulatory γδ T cells.Cell death & disease · 2019Article
- γδ T-cell responses during HIV infection and antiretroviral therapy.Clinical & translational immunology · 2019Review
- Anti-human Interleukin(IL)-4 Clone 8D4-8 Cross-Reacts With Myosin-9 Associated With Apoptotic Cells and Should Not Be Used for Flow Cytometry Applications Querying IL-4 Expression.Frontiers in cell and developmental biology · 2019Article
- The Role of IL-10 in Malaria: A Double Edged Sword.Frontiers in immunology · 2019Review
- Regulatory functions of γδ T cells.Cellular and molecular life sciences : CMLS · 2018Review
- Gamma-delta (γδ) T cells: friend or foe in cancer development?Journal of translational medicine · 2018Review
- Human Vγ9Vδ2-T Cells Synergize CD4Frontiers in immunology · 2018Article
- Protective Role ofJournal of immunology research · 2018Review
- The B-Cell Follicle in HIV Infection: Barrier to a Cure.Frontiers in immunology · 2018Review
- γδTFH cells promote B cell maturation and antibody production in neuroblastoma.BMC immunology · 2017Article
- Human γδT-cell subsets and their involvement in tumor immunity.Cellular & molecular immunology · 2017Review
- Dual Face of Vγ9Vδ2-T Cells in Tumor Immunology: Anti- versus Pro-Tumoral Activities.Frontiers in immunology · 2017Review
- A Unique Subset of γδ T Cells Expands and Produces IL-10 in Patients with Naturally Acquired Immunity against Falciparum Malaria.Frontiers in microbiology · 2017Article
- Current Advances in γδ T Cell-Based Tumor Immunotherapy.Frontiers in immunology · 2017Review
- Mucosal and Systemic γδ+ T Cells Associated with Control of Simian Immunodeficiency Virus Infection.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Article
- Five Layers of Receptor Signaling in γδ T-Cell Differentiation and Activation.Frontiers in immunology · 2015Review
Corrections and comments
- Retraction · 2019-09-24Concerns/Issues about Image · Duplication of/in Image · Manipulation of Images ·
- Retracted
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vγ9Vδ2 T lymphocytes recognize nonpeptidic antigens without presentation by MHC molecules and display pleiotropic features. Here we report that coculture of Vγ9Vδ2 cells with phosphoantigen and IL-21 leads to selective expression of the transcription repressor Bcl-6 and polarization toward a lymphocyte subset displaying features of follicular B-helper T (T(FH)) cells. T(FH)-like Vγ9Vδ2 cells have a predominant central memory (CD27(+)CD45RA(-)) phenotype and express ICOS, CD40L and CXCR5. Upon antigen activation, they secrete IL-4, IL-10 and CXCL13, and provide B-cell help for antibody production in vitro. Our findings delineate a subset of human Vγ9Vδ2 lymphocytes, which, upon interaction with IL-21-producing CD4 T(FH) cells and B cells in secondary lymphoid organs, is implicated in the production of high affinity antibodies against microbial pathogens.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.