Trial reportPloS one2012
Serum 25-hydroxyvitamin D3 and D2 and non-clinical psychotic experiences in childhood.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Relation of Vitamin D levels with positive and negative symptoms of schizophrenia - A hospital based cross-sectional comparative study.Indian journal of psychiatry · 2023Article
- Article
- Association of Air Pollution Exposure With Psychotic Experiences During Adolescence.JAMA psychiatry · 2019Article
- Association of vitamin D nutrition with neuro-developmental outcome of infants of slums in Bangladesh.PloS one · 2019Observational
- Article
- Vitamin D and mental health in children and adolescents.European child & adolescent psychiatry · 2017Review
- Low 25(OH)-vitamin D concentrations are associated with emotional and behavioral problems in German children and adolescents.PloS one · 2017Article
- Vitamin-D Deficiency As a Potential Environmental Risk Factor in Multiple Sclerosis, Schizophrenia, and Autism.Frontiers in psychiatry · 2017Review
- Vitamin D Levels in Different Severity Groups of Schizophrenia.Frontiers in psychiatry · 2017Article
- A comparison of the nutrient intake of a community-dwelling first-episode psychosis cohort, aged 19-64 years, with data from the UK population.Journal of nutritional science · 2015Article
- Vitamin D insufficiency and schizophrenia risk: evaluation of hyperprolinemia as a mediator of association.Schizophrenia research · 2014Article
- Effect of supplementation with vitamin D2-enhanced mushrooms on vitamin D status in healthy adults.Journal of nutritional science · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectiveNon-clinical psychotic experiences are common and distressing. It has been hypothesized that early life vitamin D deficiency may be a risk factor for psychosis-related outcomes, but it is not known if circulating concentrations of 25-hydroxyvitamin D (25(OH)D) during childhood are associated with psychosis-related outcomes or whether the two different forms of 25(OH)D, (25(OH)D(3) and 25(OH)D(2), have similar associations with psychosis-related outcomes.
methodsWe investigated the association between serum 25(OH)D(3) and 25(OH)D(2) concentrations and psychotic experiences in a prospective birth cohort study. Serum 25(OH)D(3) and 25(OH)D(2) concentrations were measured at mean age 9.8 years and psychotic experiences assessed at mean age 12.8 years by a psychologist (N = 3182).
resultsHigher 25(OH)D(3) concentrations were associated with lower risk of definite psychotic experiences (adjusted odds ratio: OR (95% confidence interval: CI) 0.85 (0.75-0.95)). Higher concentrations of 25(OH)D(2) were associated with higher risk of suspected and definite psychotic experiences (adjusted odds ratio: OR (95% confidence interval: CI) 1.26 (1.11, 1.43)). Higher 25(OD)D(2) concentrations were also weakly associated with definite psychotic experiences (adjusted OR (95% CI) 1.17 (0.96, 1.43), though with wide confidence intervals including the null value.
conclusionsOur findings of an inverse association of 25(OH)D(3) with definite psychotic experiences is consistent with the hypothesis that vitamin D may protect against psychosis-related outcomes.
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Registered trials
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