Trial reportPloS one2012
Human bocaviruses are not significantly associated with gastroenteritis: results of retesting archive DNA from a case control study in the UK.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Exploring evidence from cells to clinics: is human bocavirus a gastrointestinal pathogen or just a risk factor?Archives of virology · 2025Review
- Detection of Human Boca Virus in Gastric Adenocarcinoma.Middle East journal of digestive diseases · 2023Article
- Etiology of diarrheal disease among children under 5 years in Egypt: a high incidence of human bocavirus.The Journal of the Egyptian Public Health Association · 2021Article
- Human Bocavirus in Brazil: Molecular Epidemiology, Viral Load and Co-Infections.Pathogens (Basel, Switzerland) · 2020Article
- Human Bocavirus Infection Markers in Peripheral Blood and Stool Samples of Children with Acute Gastroenteritis.Viruses · 2018Article
- Human Bocavirus: Detection, Quantification and Molecular Characterization in Sewage and Surface Waters in Uruguay.Food and environmental virology · 2018Article
- Detection of Human Bocavirus Species 2 and 3 in Bivalve Shellfish in Italy.Applied and environmental microbiology · 2018Article
- Prevalence of Human Bocavirus in Africa and Other Developing Countries between 2005 and 2016: A Potential Emerging Viral Pathogen for Diarrhea.Journal of tropical medicine · 2018Review
- Relative Abundance of Human Bocaviruses in Urban Sewage in Greater Cairo, Egypt.Food and environmental virology · 2017Article
- Frequent Detection and Genetic Diversity of Human Bocavirus in Urban Sewage Samples.Food and environmental virology · 2016Article
- Mapping Antigenic Epitopes on the Human Bocavirus Capsid.Journal of virology · 2016Article
- Clinical epidemiology and molecular profiling of human bocavirus in faecal samples from children with diarrhoea in Guangzhou, China.Epidemiology and infection · 2015Article
- B-Cell Responses to Human Bocaviruses 1-4: New Insights from a Childhood Follow-Up Study.PloS one · 2015Article
- Human bocaviruses are commonly found in stools of hospitalized children without causal association to acute gastroenteritis.European journal of pediatrics · 2014Article
- The Human Bocavirus Is Associated with Some Lung and Colorectal Cancers and Persists in Solid Tumors.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastroenteritis is a common illness causing considerable morbidity and mortality worldwide. Despite improvements in detection methods, a significant diagnostic gap still remains. Human bocavirus (HBoV)s, which are associated with respiratory infections, have also frequently been detected in stool samples in cases of gastroenteritis, and a tentative association between HBoVs, and in particular type-2 HBoVs, and gastroenteritis has previously been made. The aim of this study was to determine the role of HBoVs in gastroenteritis, using archived DNA samples from the case-control Infectious Intestinal Disease Study (IID). DNA extracted from stool samples from 2,256 cases and 2,124 controls were tested for the presence of HBoV DNA. All samples were screened in a real time PCR pan-HBoV assay, and positive samples were then tested in genotype 1 to 3-specific assays. HBoV was detected in 7.4% but no significantly different prevalence was observed between cases and controls. In the genotype-specific assays 106 of the 324 HBoV-positive samples were genotyped, with HBoV-1 predominantly found in controls whilst HBoV-2 was more frequently associated with cases of gastroenteritis (p<0.01). A significant proportion of HBoV positives could not be typed using the type specific assays, 67% of the total positives, and this was most likely due to low viral loads being present in the samples. However, the distribution of the untyped HBoV strains was no different between cases and controls. In conclusion, HBoVs, including HBoV-2 do not appear to be a significant cause of gastroenteritis in the UK population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.