ArticleNucleic acids research2012
A distant cis acting intronic element induces site-selective RNA editing.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 56 citations in OpenAlex.
- RNA Pol II-dependent transcription efficiency fine-tunes A-to-I editing levels.Genome research · 2024Article
- Harnessing ADAR-Mediated Site-Specific RNA Editing in Immune-Related Disease: Prediction and Therapeutic Implications.International journal of molecular sciences · 2023Review
- Article
- RNA editing of ion channels and receptors in physiology and neurological disorders.Oxford open neuroscience · 2022Review
- RDDSVM: accurate prediction of A-to-I RNA editing sites from sequence using support vector machines.Functional & integrative genomics · 2021Article
- Review
- The Fine Art of Writing a Message: RNA Metabolism in the Shaping and Remodeling of the Nervous System.Frontiers in molecular neuroscience · 2021Review
- Genome-Wide Characterization of RNA Editing Sites in Primary Gastric Adenocarcinoma through RNA-seq Data Analysis.International journal of genomics · 2020Article
- A-to-I RNA editing - immune protector and transcriptome diversifier.Nature reviews. Genetics · 2018Review
- Increased RNA Editing May Provide a Source for Autoantigens in Systemic Lupus Erythematosus.Cell reports · 2018Article
- The landscape of miRNA editing in animals and its impact on miRNA biogenesis and targeting.Genome research · 2018Article
- Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma.Nature communications · 2017Article
- Editing inducer elements increases A-to-I editing efficiency in the mammalian transcriptome.Genome biology · 2017Article
- Promoting RNA editing by ADAR attraction.Genome biology · 2017Article
- RNA-editing enzymes ADAR1 and ADAR2 coordinately regulate the editing and expression of Ctn RNA.FEBS letters · 2017Article
- Ultraconserved Sequences Associated with HoxD Cluster Have Strong Repression Activity.Genome biology and evolution · 2017Article
- ADAR2 regulates RNA stability by modifying access of decay-promoting RNA-binding proteins.Nucleic acids research · 2017Article
- Evolutionary analysis reveals regulatory and functional landscape of coding and non-coding RNA editing.PLoS genetics · 2017Article
- Review
- Transcriptome-wide effects of inverted SINEs on gene expression and their impact on RNA polymerase II activity.Genome biology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcripts have been found to be site selectively edited from adenosine-to-inosine (A-to-I) in the mammalian brain, mostly in genes involved in neurotransmission. While A-to-I editing occurs at double-stranded structures, other structural requirements are largely unknown. We have investigated the requirements for editing at the I/M site in the Gabra-3 transcript of the GABA(A) receptor. We identify an evolutionarily conserved intronic duplex, 150 nt downstream of the exonic hairpin where the I/M site resides, which is required for its editing. This is the first time a distant RNA structure has been shown to be important for A-to-I editing. We demonstrate that the element also can induce editing in related but normally not edited RNA sequences. In human, thousands of genes are edited in duplexes formed by inverted repeats in non-coding regions. It is likely that numerous such duplexes can induce editing of coding regions throughout the transcriptome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.