ArticleThe Journal of physiology2012
A murine experimental model for the mechanical behaviour of viable right-ventricular myocardium.
Article in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed.
- Review
- Sex-Specific Interventricular Septum Mechanics in Pulmonary Arterial Hypertension.Annals of biomedical engineering · 2026Article
- Deteriorated biomechanical properties of human hypertrophied septum in response to cardiomyocyte enlargement, overexpressed collagen, and disarrayed microstructures.Frontiers in bioengineering and biotechnology · 2025Article
- Establishment of a Biaxial Testing System for Characterization of Right Ventricle Viscoelasticity Under Physiological Loadings.Cardiovascular engineering and technology · 2024Article
- Untangling the mechanisms of pulmonary arterial hypertension-induced right ventricular stiffening in a large animal model.Acta biomaterialia · 2023Article
- Untangling the mechanisms of pulmonary hypertension-induced right ventricular stiffening in a large animal model.bioRxiv : the preprint server for biology · 2023Article
- Alterations of biaxial viscoelastic properties of the right ventricle in pulmonary hypertension development in rest and acute stress conditions.Frontiers in bioengineering and biotechnology · 2023Article
- Computational models of ventricular mechanics and adaptation in response to right-ventricular pressure overload.Frontiers in physiology · 2022Review
- Multiscale Contrasts Between the Right and Left Ventricle Biomechanics in Healthy Adult Sheep and Translational Implications.Frontiers in bioengineering and biotechnology · 2022Article
- Paired Pressure-Volume Loop Analysis and Biaxial Mechanical Testing Characterize Differences in Left Ventricular Tissue Stiffness of Volume Overload and Angiotensin-Induced Pressure Overload Hearts.Journal of biomechanical engineering · 2021Article
- Right ventricular myocardial mechanics: Multi-modal deformation, microstructure, modeling, and comparison to the left ventricle.Acta biomaterialia · 2021Article
- An exploratory assessment of stretch-induced transmural myocardial fiber kinematics in right ventricular pressure overload.Scientific reports · 2021Article
- The Effects of Healthy Aging on Right Ventricular Structure and Biomechanical Properties: A Pilot Study.Frontiers in medicine · 2021Article
- Current Understanding of the Right Ventricle Structure and Function in Pulmonary Arterial Hypertension.Frontiers in physiology · 2021Review
- Angiotensin Receptor-Neprilysin Inhibition Attenuates Right Ventricular Remodeling in Pulmonary Hypertension.Journal of the American Heart Association · 2020Article
- Current Understanding of the Biomechanics of Ventricular Tissues in Heart Failure.Bioengineering (Basel, Switzerland) · 2019Review
- A Computational Cardiac Model for the Adaptation to Pulmonary Arterial Hypertension in the Rat.Annals of biomedical engineering · 2019Article
- Transmural remodeling of right ventricular myocardium in response to pulmonary arterial hypertension.APL bioengineering · 2017Article
- Biomechanical and Hemodynamic Measures of Right Ventricular Diastolic Function: Translating Tissue Biomechanics to Clinical Relevance.Journal of the American Heart Association · 2017Article
- A novel constitutive model for passive right ventricular myocardium: evidence for myofiber-collagen fiber mechanical coupling.Biomechanics and modeling in mechanobiology · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Although right-ventricular function is an important determinant of cardio-pulmonary performance in health and disease, right ventricular myocardium mechanical behaviour has received relatively little attention. We present a novel experimental method for quantifying the mechanical behaviour of transmurally intact, viable right-ventricular myocardium. Seven murine right ventricular free wall (RVFW) specimens were isolated and biaxial mechanical behaviour measured, along with quantification of the local transmural myofibre and collagen fibre architecture. We developed a complementary strain energy function based method to capture the average biomechanical response. Overall, murine RVFW revealed distinct mechanical anisotropy. The preferential alignment of the myofibres and collagen fibres to the apex-to-outflow-tract direction was consistent with this also being the mechanically stiffer axis. We also observed that the myofibre and collagen fibre orientations were remarkably uniform throughout the entire RVFW thickness. Thus, our findings indicate a close correspondence between the tissue microstructure and biomechanical behaviour of the RVFW myocardium, and are a first step towards elucidating the structure–function of non-contracted murine RVFW myocardium in health and disease.
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Registered trials
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