ArticleJournal of biomedical materials research. Part B, Applied biomaterials2012
Bone healing response to a synthetic calcium sulfate/β-tricalcium phosphate graft material in a sheep vertebral body defect model.
Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05706909 (The Use of Genex in the Management of Early-Stage Osteonecrosis of the Femoral Head), which is not on this map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Use of Genex in the Management of Early-Stage Osteonecrosis of the Femoral Head
Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- A Retrospective Study Using a Novel Body-Shift Implant Design with a Novel Alloplastic Particulate Grafting Material in Immediate Extraction Sockets.European journal of dentistry · 2025Article
- Two decades of continuous progresses and breakthroughs in the field of bioactive ceramics and glasses driven by CICECO-hub scientists.Bioactive materials · 2024Review
- Limitations and modifications in the clinical application of calcium sulfate.Frontiers in surgery · 2024Review
- Injectable Synthetic Beta-Tricalcium Phosphate/Calcium Sulfate (GeneX) for the Management of Contained Defects Following Curettage of Benign Bone Tumours.Current oncology (Toronto, Ont.) · 2023Article
- Injectable bone cements: What benefits the combination of calcium phosphates and bioactive glasses could bring?Bioactive materials · 2023Review
- Large Animal Model of Osteoporotic Defect Healing: An Alternative to Metaphyseal Defect Model.Life (Basel, Switzerland) · 2021Article
- Antibiotic loaded β-tricalcium phosphate/calcium sulfate for antimicrobial potency, prevention and killing efficacy of Pseudomonas aeruginosa and Staphylococcus aureus biofilms.Scientific reports · 2021Article
- An overview of de novo bone generation in animal models.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Review
- Treatment of Osseous Defects after Mandibular Third Molar Removal with a Resorbable Alloplastic Grafting Material: A Case Series with 1- to 2-Year Follow-Up.Materials (Basel, Switzerland) · 2020Article
- Osseous Healing in Surgically Prepared Bone Defects Using Different Grafting Materials: An Experimental Study in Pigs.Dentistry journal · 2020Article
- Bone Healing in Rabbit Calvaria Defects Using a Synthetic Bone Substitute: A Histological and Micro-CT Comparative Study.Materials (Basel, Switzerland) · 2018Article
- Is calcium phosphate augmentation a viable option for osteoporotic hip fractures?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- Clinical experience with the artificial bone graft substitute Calcibon used following curettage of benign and low-grade malignant bone tumors.Scientific reports · 2017Article
- The biocompatibility of bone cements: progress in methodological approach.European journal of histochemistry : EJH · 2017Article
- Prophylactic vertebroplasty procedure applied with a resorbable bone cement can decrease the fracture risk of sandwich vertebrae: long-term evaluation of clinical outcomes.Regenerative biomaterials · 2017Article
- Calcium phosphate cements for bone engineering and their biological properties.Bone research · 2017Review
- Multiplex gene editing via CRISPR/Cas9 exhibits desirable muscle hypertrophy without detectable off-target effects in sheep.Scientific reports · 2016Article
- PTH Induces Systemically Administered Mesenchymal Stem Cells to Migrate to and Regenerate Spine Injuries.Molecular therapy : the journal of the American Society of Gene Therapy · 2016Article
- Lytic Complications after Skull Reconstruction Using GeneX®.Korean journal of neurotrauma · 2015Article
- Bone defect animal models for testing efficacy of bone substitute biomaterials.Journal of orthopaedic translation · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The introduction of a material able to promote osteogenesis and remodelling activity in a clinically relevant time frame in vertebroplasty and kyphoplasty procedures may have patient benefit. We report the in-vivo performance of a biphasic synthetic bone graft material (Genex Paste, Biocomposites, UK) [test material], composed of calcium sulfate and β-tricalcium phosphate, implanted into a sheep vertebral defect model. Cavities drilled into 4 adjacent vertebrae (L2 to L5) of 24 skeletally mature sheep were; (1) filled with the test material; (2) filled with commercially available polymethylmethacrylate [PMMA] cement; (3) remained empty [sham]. Analysis was performed immediately after implantation and at 8, 16, and 36 weeks post implantation. Sites were evaluated for bone growth with microCT analysis, histological examination, and mechanical testing under compression. The test material exhibited an improved tissue response over the PMMA, indicating a superior biological tolerance. MicroCT and histology indicated marked osteoregenerative capacity of the test material when compared with sham and the PMMA. The percentage of new bone formation was higher for the test material than sham at 16 and 36 weeks post implantation, with bone regeneration almost complete at 36 weeks in this group. Resorption of test material and the integration into new bone tissue were demonstrated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.