ArticleChemMedChem2012
Evaluation of flavonoid and resveratrol chemical libraries reveals abyssinone II as a promising antibacterial lead.
Article in ChemMedChem, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Exploring the application of herbal photosensitizers in antimicrobial photodynamic therapy against3 Biotech · 2025Review
- Prenylated Flavonoids of the Moraceae Family: A Comprehensive Review of Their Biological Activities.Plants (Basel, Switzerland) · 2024Review
- Antimicrobial Peptides: The Production of Novel Peptide-Based Therapeutics in Plant Systems.Life (Basel, Switzerland) · 2023Review
- Antibacterial, Antibiofilm, and Antioxidant Activity of 15 Different Plant-Based Natural Compounds in Comparison with Ciprofloxacin and Gentamicin.Antibiotics (Basel, Switzerland) · 2022Article
- Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens.Journal of natural products · 2022Review
- Autophagy as a Target for Drug Development Of Skin Infection Caused by Mycobacteria.Frontiers in immunology · 2021Review
- Sirtuin 3 is essential for host defense againstVirulence · 2020Article
- The War against Tuberculosis: A Review of Natural Compounds and Their Derivatives.Molecules (Basel, Switzerland) · 2020Review
- Pharmacophore Modeling, Synthesis, and Antibacterial Evaluation of Chalcones and Derivatives.ACS omega · 2018Article
- Investigation of the anti-TB potential of selected propolis constituents using a molecular docking approach.Scientific reports · 2018Article
- Membrane Interactions of Phytochemicals as Their Molecular Mechanism Applicable to the Discovery of Drug Leads from Plants.Molecules (Basel, Switzerland) · 2015Review
- Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives.Journal of medicinal chemistry · 2014Article
- Chemical modulation of the biological activity of reutericyclin: a membrane-active antibiotic from Lactobacillus reuteri.Scientific reports · 2014Article
- Prospects for flavonoid and related phytochemicals as nature-inspired treatments for Clostridium difficile infection.Journal of applied microbiology · 2014Article
- Synthesis and antibacterial evaluation of anziaic acid and analogues as topoisomerase I inhibitors.MedChemComm · 2013Article
- Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular and antibacterial agents.The Journal of antibiotics · 2013Article
- Emerging targets in lipid-based therapy.Biochemical pharmacology · 2013Review
- Recent advances in the use of resveratrol againstMedicine internationalReview
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Lead on! In the course of screening flavonoid and resveratrol libraries, abyssinone II, a naturally occurring prenylated flavonoid, was found to exhibit relatively good antitubercular and antibacterial activity. Preliminary mechanistic studies revealed that abyssinone II hyperpolarizes the bacterial membrane potential and inhibits the biosynthesis of key cellular macromolecules (DNA, RNA, and protein).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.