ArticleEnvironmental and molecular mutagenesis2012
DNA methylation alterations in response to pesticide exposure in vitro.
Article in Environmental and molecular mutagenesis, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 83 citations in OpenAlex.
- Transgenerational somatic mutations and epigenetic imprints on selected DNA repair gene promoters in Arabidopsis thaliana due to pesticides.Plant biology (Stuttgart, Germany) · 2026Article
- Sex andToxics · 2026Article
- Occupational pesticide use and relative leukocyte telomere length in the biomarkers of exposure and effect in agriculture study.Environmental research · 2025Article
- DNA methylation in the association between pesticide exposures and type 2 diabetes.World journal of diabetes · 2025Article
- Organochlorine Pesticides and Epigenetic Alterations in Brain Cancer.Cellular and molecular neurobiology · 2025Article
- DNA Methylation Profiling in Genetically Selected Clarias magur (Hamilton, 1822) Provides Insights into the Epigenetic Regulation of Growth and Development.Marine biotechnology (New York, N.Y.) · 2024Article
- Identification of common genetic factors and immune-related pathways associating more than two autoimmune disorders: implications on risk, diagnosis, and treatment.Genomics & informatics · 2024Article
- Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro.International journal of molecular sciences · 2023Article
- A Review on Epigenetic Inheritance of Experiences in Humans.Biochemical genetics · 2022Review
- Antioxidative Defense and Gut Microbial Changes under Pollution Stress inInternational journal of environmental research and public health · 2022Article
- Pesticides: formulants, distribution pathways and effects on human health - a review.Toxicology reports · 2021Review
- Sex and Exposure to Postnatal Chlorpyrifos Influence the Epigenetics of Feeding-Related Genes in a TransgenicInternational journal of environmental research and public health · 2020Article
- Different working conditions shift the genetic damage levels of pesticide-exposed agriculture workers.Environmental science and pollution research international · 2020Article
- Organophosphate toxicity: updates of malathion potential toxic effects in mammals and potential treatments.Environmental science and pollution research international · 2020Review
- Pesticide Poisoning and the Use of Personal Protective Equipment (PPE) in Indonesian Farmers.Journal of environmental and public health · 2020Article
- Modified CDKN2B (p15) and CDKN2A (p16) DNA methylation profiles in urban pesticide applicators.Environmental science and pollution research international · 2019Article
- Organophosphate pesticide exposure and differential genome-wide DNA methylation.The Science of the total environment · 2018Article
- Mechanisms of organophosphorus pesticide toxicity in the context of airway hyperreactivity and asthma.American journal of physiology. Lung cellular and molecular physiology · 2018Review
- Occupational exposure to pesticides is associated with differential DNA methylation.Occupational and environmental medicine · 2018Article
- DNA methylation 101: what is important to know about DNA methylation and its role in SLE risk and disease heterogeneity.Lupus science & medicine · 2018Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Although pesticides are subject to extensive carcinogenicity testing before regulatory approval, pesticide exposure has repeatedly been associated with various cancers. This suggests that pesticides may cause cancer via nonmutagenicity mechanisms. The present study provides evidence to support the hypothesis that pesticide-induced cancer may be mediated in part by epigenetic mechanisms. We examined whether exposure to seven commonly used pesticides (i.e., fonofos, parathion, terbufos, chlorpyrifos, diazinon, malathion, and phorate) induces DNA methylation alterations in vitro. We conducted genome-wide DNA methylation analyses on DNA samples obtained from the human hematopoietic K562 cell line exposed to ethanol (control) and several organophosphate pesticides (OPs) using the Illumina Infinium HumanMethylation27 BeadChip. Bayesian-adjusted t-tests were used to identify differentially methylated gene promoter CpG sites. In this report, we present our results on three pesticides (fonofos, parathion, and terbufos) that clustered together based on principle component analysis and hierarchical clustering. These three pesticides induced similar methylation changes in the promoter regions of 712 genes, while also exhibiting their own OP-specific methylation alterations. Functional analysis of methylation changes specific to each OP, or common to all three OPs, revealed that differential methylation was associated with numerous genes that are involved in carcinogenesis-related processes. Our results provide experimental evidence that pesticides may modify gene promoter DNA methylation levels, suggesting that epigenetic mechanisms may contribute to pesticide-induced carcinogenesis. Further studies in other cell types and human samples are required, as well as determining the impact of these methylation changes on gene expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.