ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2012
Predicting nucleosome binding motif set and analyzing their distributions around functional sites of human genes.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 citing papers in PubMed, 24 citations in OpenAlex.
- Exploring objective feature sets in constructing the evolution relationship of animal genome sequences.BMC genomics · 2023Article
- Intrinsic laws of k-mer spectra of genome sequences and evolution mechanism of genomes.BMC evolutionary biology · 2020Article
- Evolutionary mechanism and biological functions of 8-mers containing CG dinucleotide in yeast.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2017Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Nucleosome positioning and remodeling correlate closely with the DNA sequence bias. It is possible that DNA motifs, interacted preferentially with histone octamers, direct the nucleosome positioning. Exploring the complete set of nucleosome binding motifs is of crucial importance for our understanding of the roles of nucleosomes in gene regulation. Based on the 8-mer multimodal spectra of the human genome, a systematic nucleosome binding motif set is inferred. Its structural features and density distributions for different types of sequences are consistent with the published data. Distributions of these motifs around several functional sites could describe the ground state of nucleosome distribution of these regions. Our results strongly support that the predicted nucleosome binding motif set is reliable. Our findings indicate that the recognition of distinct functional sites or sequences could be greatly improved by the help of a nucleosome array.
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