ReviewJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2013
Determinants of intra-specific variation in basal metabolic rate.
Review in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 168 citations in OpenAlex.
- Pervasive effects ofbioRxiv : the preprint server for biology · 2026Article
- Links between mitochondrial function, whole-animal metabolic rate, telomere dynamics and swimming performance in minnows.The Journal of experimental biology · 2026Article
- Nutrigenomics of Obesity: Integrating Genomics, Epigenetics, and Diet-Microbiome Interactions for Precision Nutrition.Life (Basel, Switzerland) · 2025Review
- Resting metabolic rate is repeatable, but does not affect call characteristics, in the gray treefrog Hyla chrysoscelis.The Journal of experimental biology · 2025Article
- The metabolic costs of meiotic drive.Proceedings. Biological sciences · 2025Article
- Basal metabolic rate shapes the development and progression of hepatocellular carcinoma.BMC cancer · 2025Article
- Lactation at hot temperature: a test of heat dissipation limitation in mice divergently selected for basal metabolic rate.Biology letters · 2025Article
- Impacts of Endogenous Factors and Ontogenetic Stages on the Metabolic Rate of the Mediterranean Spider CrabIntegrative organismal biology (Oxford, England) · 2025Article
- Effects of sublethal methylmercury and food stress on songbird energetic performance: metabolic rates, molt and feather quality.The Journal of experimental biology · 2024Article
- Interactive effects of intrinsic and extrinsic factors on metabolic rate.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Metabolic scaling as an emergent outcome of variation in metabolic rate.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Data needs for sea otter bioenergetics modeling.Conservation physiology · 2024Article
- Intra-Assessment Resting Metabolic Rate Variability Is Associated with Cardiometabolic Risk Factors in Middle-Aged Adults.Journal of clinical medicine · 2023Article
- Recovery from FOLFOX chemotherapy-induced systemic and skeletal muscle metabolic dysfunction in mice.American journal of physiology. Endocrinology and metabolism · 2023Article
- Energy expenditure and body composition in a hibernator, the alpine marmot.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2023Article
- Cell size, body size and Peto's paradox.BMC ecology and evolution · 2022Review
- Associations between Intra-Assessment Resting Metabolic Rate Variability and Health-Related Factors.Metabolites · 2022Article
- Genomics and morphometrics reveal the adaptive evolution of pikas.Zoological research · 2022Article
- How Metabolic Rate Relates to Cell Size.Biology · 2022Review
- Mice selected for a high basal metabolic rate evolved larger guts but not more efficient mitochondria.Proceedings. Biological sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Basal metabolic rate (BMR) provides a widely accepted benchmark of metabolic expenditure for endotherms under laboratory and natural conditions. While most studies examining BMR have concentrated on inter-specific variation, relatively less attention has been paid to the determinants of within-species variation. Even fewer studies have analysed the determinants of within-species BMR variation corrected for the strong influence of body mass by appropriate means (e.g. ANCOVA). Here, we review recent advancements in studies on the quantitative genetics of BMR and organ mass variation, along with their molecular genetics. Next, we decompose BMR variation at the organ, tissue and molecular level. We conclude that within-species variation in BMR and its components have a clear genetic signature, and are functionally linked to key metabolic process at all levels of biological organization. We highlight the need to integrate molecular genetics with conventional metabolic field studies to reveal the adaptive significance of metabolic variation. Since comparing gene expressions inter-specifically is problematic, within-species studies are more likely to inform us about the genetic underpinnings of BMR. We also urge for better integration of animal and medical research on BMR; the latter is quickly advancing thanks to the application of imaging technologies and 'omics' studies. We also suggest that much insight on the biochemical and molecular underpinnings of BMR variation can be gained from integrating studies on the mammalian target of rapamycin (mTOR), which appears to be the major regulatory pathway influencing the key molecular components of BMR.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.