ArticleProceedings of the National Academy of Sciences of the United States of America2012
Selfish supernumerary chromosome reveals its origin as a mosaic of host genome and organellar sequences.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.
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123 citing papers in PubMed.
- Molecular divergence and genomic composition of B chromosomes in the fish Cyphocharax modestus (Characiformes, Curimatidae).Scientific reports · 2026Article
- Review
- B chromosomes put the 'super' in supernumerary.Trends in genetics : TIG · 2026Review
- Genetic and Epigenetic Mechanisms Underlying Reversible Adaptive Responses in Fungi.Journal of fungi (Basel, Switzerland) · 2026Review
- Polymorphism and evolutionary origins of accessory chromosomes in the basidiomycete Tremella fuciformis.Nature communications · 2026Article
- Sorghum embryos undergoing B chromosome elimination express B-variants of mitotic-related genes.Genome biology · 2025Article
- Genome assembly of the maize B chromosome provides insight into its epigenetic characteristics and effects on the host genome.Genome biology · 2025Article
- Telomere-to-telomere Phragmites australis reference genome assembly with a B chromosome provides insights into its evolution and polysaccharide biosynthesis.Communications biology · 2025Article
- Pan-phylum genomes of hornworts reveal conserved autosomes but dynamic accessory and sex chromosomes.Nature plants · 2025Article
- Dynamic meiotic behavior and evolutionary insights of supernumerary B chromosomes in the hangingflyComparative cytogenetics · 2025Article
- The genetic mechanism of B chromosome drive in rye illuminated by chromosome-scale assembly.Nature communications · 2024Article
- Article
- Article
- Response to correspondence on "B chromosomes of multiple species have intense evolutionary dynamics and accumulated genes related to important biological processes".BMC genomics · 2023Article
- Rapid gene content turnover on the germline-restricted chromosome in songbirds.Nature communications · 2023Article
- First Update to B-Chrom: A Database on B-Chromosomes.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Flow Cytometric Analysis and Sorting of Plant Chromosomes.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Rye B chromosomes differently influence the expression of A chromosome-encoded genes depending on the host species.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2022Article
- First characterization of PIWI-interacting RNA clusters in a cichlid fish with a B chromosome.BMC biology · 2022Article
- The non-Mendelian behavior of plant B chromosomes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2022Review
63 more citing papers are in PubMed but not listed here.
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20 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Supernumerary B chromosomes are optional additions to the basic set of A chromosomes, and occur in all eukaryotic groups. They differ from the basic complement in morphology, pairing behavior, and inheritance and are not required for normal growth and development. The current view is that B chromosomes are parasitic elements comparable to selfish DNA, like transposons. In contrast to transposons, they are autonomously inherited independent of the host genome and have their own mechanisms of mitotic or meiotic drive. Although B chromosomes were first described a century ago, little is known about their origin and molecular makeup. The widely accepted view is that they are derived from fragments of A chromosomes and/or generated in response to interspecific hybridization. Through next-generation sequencing of sorted A and B chromosomes, we show that B chromosomes of rye are rich in gene-derived sequences, allowing us to trace their origin to fragments of A chromosomes, with the largest parts corresponding to rye chromosomes 3R and 7R. Compared with A chromosomes, B chromosomes were also found to accumulate large amounts of specific repeats and insertions of organellar DNA. The origin of rye B chromosomes occurred an estimated ∼1.1-1.3 Mya, overlapping in time with the onset of the genus Secale (1.7 Mya). We propose a comprehensive model of B chromosome evolution, including its origin by recombination of several A chromosomes followed by capturing of additional A-derived and organellar sequences and amplification of B-specific repeats.
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