ArticleProceedings of the National Academy of Sciences of the United States of America2012
Molecular basis for the specification of floral organs by APETALA3 and PISTILLATA.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 1 of them a synthesis that pooled it.
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Who cites it
120 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Analysis of the arabidopsis REM gene family predicts functions during flower development.Annals of botany · 2014Pooled it
- The petal identity geneeLife · 2026Article
- Two LEAFY homologs regulate floral patterning and development without affecting flowering time in kiwifruit.Journal of experimental botany · 2026Article
- Centromere organization and epigenetic regulation in Aristolochia fimbriata.Genome biology · 2026Article
- Genome-Wide Identification of miRNAs and Pollen-Associated miRNA-Target Relationships inPlants (Basel, Switzerland) · 2026Article
- Imputation integrates single-cell and spatial gene expression data to resolve transcriptional networks in barley shoot meristem development.Nature plants · 2026Article
- AP1 is a pioneer transcription factor that programmes cell fate through MADS-domain protein tetramerisation.Genome biology · 2025Article
- Promoter Motif Profiling and Binding Site Distribution Analysis of Transcription Factors Predict Auto- and Cross-Regulatory Mechanisms inInternational journal of molecular sciences · 2025Article
- Transcription factor BrEFM negatively regulates flowering time in Chinese cabbage.Functional & integrative genomics · 2025Article
- Chronology of transcriptome and proteome expression during early Arabidopsis flower development.Journal of experimental botany · 2025Article
- FD and FDP bZIP transcription factors and FT florigen regulate floral development and control homeotic gene expression in Arabidopsis floral meristems.Development (Cambridge, England) · 2025Article
- Expression variation of Viola APETALA3 orthologous genes is correlated with chasmogamous and cleistogamous flower development.BMC plant biology · 2025Article
- Building beauty: Understanding how hormone signaling regulates petal patterning and morphogenesis.The Plant journal : for cell and molecular biology · 2025Review
- Genome-Wide Investigation ofInternational journal of molecular sciences · 2025Article
- The homeotic gene PhDEF regulates production of volatiles in petunia flowers by activating EOBI and EOBII.The Plant cell · 2025Article
- Article
- Single-cell transcriptomic and cell‑type‑specific regulatory networks in Polima temperature-sensitive cytoplasmic male sterility of Brassica napus L.BMC plant biology · 2024Article
- The overall regulatory network and contributions of ABC(D)E model genes in yellowhorn flower development.BMC plant biology · 2024Article
- Morphological and molecular mechanisms of floral nectary development in Chinese Jujube.BMC plant biology · 2024Article
- 'Organ'ising Floral Organ Development.Plants (Basel, Switzerland) · 2024Review
60 more citing papers are in PubMed but not listed here.
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10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How different organs are formed from small sets of undifferentiated precursor cells is a key question in developmental biology. To understand the molecular mechanisms underlying organ specification in plants, we studied the function of the homeotic selector genes APETALA3 (AP3) and PISTILLATA (PI), which control the formation of petals and stamens during Arabidopsis flower development. To this end, we characterized the activities of the transcription factors that AP3 and PI encode throughout flower development by using perturbation assays as well as transcript profiling and genomewide localization studies, in combination with a floral induction system that allows a stage-specific analysis of flower development by genomic technologies. We discovered considerable spatial and temporal differences in the requirement for AP3/PI activity during flower formation and show that they control different sets of genes at distinct phases of flower development. The genomewide identification of target genes revealed that AP3/PI act as bifunctional transcription factors: they activate genes involved in the control of numerous developmental processes required for organogenesis and repress key regulators of carpel formation. Our results imply considerable changes in the composition and topology of the gene network controlled by AP3/PI during the course of flower development. We discuss our results in light of a model for the mechanism underlying sex-determination in seed plants, in which AP3/PI orthologues might act as a switch between the activation of male and the repression of female development.
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