ArticleProceedings of the National Academy of Sciences of the United States of America2012
Pathological crystallization of human immunoglobulins.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Cryoglobulinemia, monoclonal and mixed cryoglobulinemia syndromes, cryoglobulinemic vasculitis:Frontiers in immunology · 2026Review
- Anti-cytokine autoantibodies: mechanistic insights and disease associations.Nature reviews. Immunology · 2024Review
- Decorated networks of native proteins: nanomaterials with tunable mesoscopic domain size.Soft matter · 2021Article
- [A case of cryocrystalglobulinemia with microvascular embolization as the first manifestation and literature review].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2019Review
- A stepwise mechanism for aqueous two-phase system formation in concentrated antibody solutions.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Metastability Gap in the Phase Diagram of Monoclonal IgG Antibody.Biophysical journal · 2017Article
- Elasticity in Macrophage-Synthesized Biocrystals.Angewandte Chemie (International ed. in English) · 2017Article
- Diagnostics and treatment of cryoglobulinaemia: it takes two to tango.Clinical reviews in allergy & immunology · 2014Review
- In cellulo structure determination of a novel cypovirus polyhedrin.Acta crystallographica. Section D, Biological crystallography · 2014Article
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- Phase transitions in human IgG solutions.The Journal of chemical physics · 2013Article
- Aggregates, crystals, gels, and amyloids: intracellular and extracellular phenotypes at the crossroads of immunoglobulin physicochemical property and cell physiology.International journal of cell biology · 2013Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Condensation of Igs has been observed in pharmaceutical formulations and in vivo in cases of cryoglobulinemia. We report a study of monoclonal IgG cryoglobulins overexpressed by two patients with multiple myeloma. These cryoglobulins form crystals, and we measured their solubility lines. Depending on the supersaturation, we observed a variety of condensate morphologies consistent with those reported in clinical investigations. Remarkably, the crystallization can occur at quite low concentrations. This suggests that, even within the regular immune response to infections, cryoprecipitation of Ig can be possible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.