ArticleProceedings of the National Academy of Sciences of the United States of America2012
Designed guanidinium-rich amphipathic oligocarbonate molecular transporters complex, deliver and release siRNA in cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed.
- Discrete Immolative Guanidinium Transporters deliver mRNA to specific organs and red blood cells.Nature communications · 2025Article
- Isoprenoid CARTs:Biomacromolecules · 2024Article
- Organ- and Cell-Selective Delivery of mRNA In Vivo Using Guanidinylated Serinol Charge-Altering Releasable Transporters.Journal of the American Chemical Society · 2024Article
- Detection of intact vancomycin-arginine as the active antibacterial conjugate inRSC medicinal chemistry · 2023Article
- Complexation Preferences of Dynamic Constitutional Frameworks as Adaptive Gene Vectors.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- PEI fluorination reduces toxicity and promotes liver-targeted siRNA delivery.Drug delivery and translational research · 2021Article
- Micelles Based on Lysine, Histidine, or Arginine: Designing Structures for Enhanced Drug Delivery.Frontiers in bioengineering and biotechnology · 2021Review
- Bioactive Aliphatic Polycarbonates Carrying Guanidinium Functions: An Innovative Approach for Myotonic Dystrophy Type 1 Therapy.ACS omega · 2019Article
- A Dual-Function Antibiotic-Transporter Conjugate Exhibits Superior Activity in Sterilizing MRSA Biofilms and Killing Persister Cells.Journal of the American Chemical Society · 2018Article
- Delivery of Inorganic Polyphosphate into Cells Using Amphipathic Oligocarbonate Transporters.ACS central science · 2018Article
- Protein Transduction Domain Mimic (PTDM) Self-Assembly?Polymers · 2018Article
- Functional DNA Delivery Enabled by Lipid-Modified Charge-Altering Releasable Transporters (CARTs).Biomacromolecules · 2018Article
- Enhanced mRNA delivery into lymphocytes enabled by lipid-varied libraries of charge-altering releasable transporters.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Guanidinium-Functionalized Interpolyelectrolyte Complexes Enabling RNAi in Resistant Insect Pests.Biomacromolecules · 2018Article
- A macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset.Nature communications · 2018Article
- Dual-Function Polymeric HPMA Prodrugs for the Delivery of miRNA.Molecular pharmaceutics · 2017Article
- Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Fast and selective ring-opening polymerizations by alkoxides and thioureas.Nature chemistry · 2016Article
- Mapping Optimal Charge Density and Length of ROMP-Based PTDMs for siRNA Internalization.Biomacromolecules · 2016Article
- Optimal Hydrophobicity in Ring-Opening Metathesis Polymerization-Based Protein Mimics Required for siRNA Internalization.Biomacromolecules · 2016Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The polyanionic nature of oligonucleotides and their enzymatic degradation present challenges for the use of siRNA in research and therapy; among the most notable of these is clinically relevant delivery into cells. To address this problem, we designed and synthesized the first members of a new class of guanidinium-rich amphipathic oligocarbonates that noncovalently complex, deliver, and release siRNA in cells, resulting in robust knockdown of target protein synthesis in vitro as determined using a dual-reporter system. The organocatalytic oligomerization used to synthesize these co-oligomers is step-economical and broadly tunable, affording an exceptionally quick strategy to explore chemical space for optimal siRNA delivery in varied applications. The speed and versatility of this approach and the biodegradability of the designed agents make this an attractive strategy for biological tool development, imaging, diagnostics, and therapeutic applications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.