ArticleProceedings of the National Academy of Sciences of the United States of America2012
A molecular method for the delivery of small molecules and proteins across the cell wall of algae using molecular transporters.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 56 citations in OpenAlex.
- Cell-Penetrating Peptide-Based Triple Nanocomplex Enables Efficient Nuclear Gene Delivery in Chlamydomonas reinhardtii.Biotechnology and bioengineering · 2025Article
- The need for smart microalgal bioprospecting.Natural products and bioprospecting · 2025Review
- Biohybrid Microalgae Robots: Design, Fabrication, Materials, and Applications.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- Detection of intact vancomycin-arginine as the active antibacterial conjugate inRSC medicinal chemistry · 2023Article
- Extremophile-based biohybrid micromotors for biomedical operations in harsh acidic environments.Science advances · 2022Article
- Combination of vancomycin and guanidinium-functionalized helical polymers for synergistic antibacterial activity and biofilm ablation.Chemical science · 2022Article
- Review
- Reduced cytotoxicity of polyethyleneimine by covalent modification of antioxidant and its application to microalgal transformation.Science and technology of advanced materials · 2021Article
- Development of a pVEC peptide-based ribonucleoprotein (RNP) delivery system for genome editing using CRISPR/Cas9 in Chlamydomonas reinhardtii.Scientific reports · 2020Article
- Genetic transformation of3 Biotech · 2019Article
- A Dual-Function Antibiotic-Transporter Conjugate Exhibits Superior Activity in Sterilizing MRSA Biofilms and Killing Persister Cells.Journal of the American Chemical Society · 2018Article
- Ion and metabolite transport in the chloroplast of algae: lessons from land plants.Cellular and molecular life sciences : CMLS · 2018Review
- Peptide-drug conjugates as effective prodrug strategies for targeted delivery.Advanced drug delivery reviews · 2017Review
- Article
- Polymyxins Facilitate Entry into Mammalian Cells.Chemical science · 2016Article
- PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery.Nature communications · 2016Article
- Cell-Penetrating, Guanidinium-Rich Oligophosphoesters: Effective and Versatile Molecular Transporters for Drug and Probe Delivery.Journal of the American Chemical Society · 2016Article
- Functionalized Buckyballs for Visualizing Microbial Species in Different States and Environments.Scientific reports · 2015Article
- Guanidinium-rich, glycerol-derived oligocarbonates: a new class of cell-penetrating molecular transporters that complex, deliver, and release siRNA.Molecular pharmaceutics · 2015Article
- Fifteen years of cell-penetrating, guanidinium-rich molecular transporters: basic science, research tools, and clinical applications.Accounts of chemical research · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Interest in algae has significantly accelerated with the increasing recognition of their potentially unique role in medical, materials, energy, bioremediation, and synthetic biological research. However, the introduction of tools to study, control, or expand the inner-workings of algae has lagged behind. Here we describe a general molecular method based on guanidinium-rich molecular transporters (GR-MoTrs) for bringing small and large cargos into algal cells. Significantly, this method is shown to work in wild-type algae that have an intact cell wall. Developed using Chlamydomonas reinhardtii, this method is also successful with less studied algae including Neochloris oleoabundans and Scenedesmus dimorphus thus providing a new and versatile tool for algal research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.