ArticleJournal of the American Society for Mass Spectrometry2012
Analysis of renal cell carcinoma as a first step for developing mass spectrometry-based diagnostics.
Article in Journal of the American Society for Mass Spectrometry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 64 citations in OpenAlex.
- Metabolomics for the Identification of Biomarkers in Kidney Diseases.Nanotheranostics · 2025Review
- Lipid metabolism reprogramming in renal cell carcinomas.Medical oncology (Northwood, London, England) · 2024Review
- Diagnostic method of mass spectrometry for detecting lymph node metastasis of non-small cell lung cancer.Thoracic cancer · 2024Article
- Lipid metabolism reprogramming in renal cell carcinoma.Cancer metastasis reviews · 2022Review
- Utility of mass spectrometry and artificial intelligence for differentiating primary lung adenocarcinoma and colorectal metastatic pulmonary tumor.Thoracic cancer · 2022Article
- Direct Liquid Extraction and Ionization Techniques for Understanding Multimolecular Environments in Biological Systems (Secondary Publication).Mass spectrometry (Tokyo, Japan) · 2021Article
- Rapid automated diagnosis of primary hepatic tumour by mass spectrometry and artificial intelligence.Liver international : official journal of the International Association for the Study of the Liver · 2020Article
- Breast cancer diagnosis based on lipid profiling by probe electrospray ionization mass spectrometry.The British journal of surgery · 2020Article
- Identification of novel biomarkers of hepatocellular carcinoma by high-definition mass spectrometry: Ultrahigh-performance liquid chromatography quadrupole time-of-flight mass spectrometry and desorption electrospray ionization mass spectrometry imaging.Rapid communications in mass spectrometry : RCM · 2020Article
- Probe Electrospray Ionization (PESI) and Its Modified Versions: Dipping PESI (dPESI), Sheath-Flow PESI (sfPESI) and Adjustable sfPESI (ad-sfPESI).Mass spectrometry (Tokyo, Japan) · 2020Article
- Article
- Genetic and metabolic hallmarks of clear cell renal cell carcinoma.Biochimica et biophysica acta. Reviews on cancer · 2018Review
- Metabolomic study of human tissue and urine in clear cell renal carcinoma by LC-HRMS and PLS-DA.Analytical and bioanalytical chemistry · 2018Article
- Detection of potential new biomarkers of atherosclerosis by probe electrospray ionization mass spectrometry.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- Analysis of human gliomas by swab touch spray-mass spectrometry: applications to intraoperative assessment of surgical margins and presence of oncometabolites.The Analyst · 2017Article
- Ambient mass spectrometry in metabolomics.The Analyst · 2017Review
- Addressing metabolic heterogeneity in clear cell renal cell carcinoma with quantitative Dixon MRI.JCI insight · 2017Article
- Towards Practical Endoscopic Mass Spectrometry.Mass spectrometry (Tokyo, Japan) · 2017Article
- Desorption in Mass Spectrometry.Mass spectrometry (Tokyo, Japan) · 2017Article
- Secondary Ion Mass Spectrometry Analysis of Renal Cell Carcinoma with Electrospray Droplet Ion Beams.Mass spectrometry (Tokyo, Japan) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immediate diagnosis of human specimen is an essential prerequisites in medical routines. This study aimed to establish a novel cancer diagnostics system based on probe electrospray ionization-mass spectrometry (PESI-MS) combined with statistical data processing. PESI-MS uses a very fine acupuncture needle as a probe for sampling as well as for ionization. To demonstrate the applicability of PESI-MS for cancer diagnosis, we analyzed nine cases of clear cell renal cell carcinoma (ccRCC) by PESI-MS and processed the data by principal components analysis (PCA). Our system successfully delineated the differences in lipid composition between non-cancerous and cancerous regions. In this case, triacylglycerol (TAG) was reproducibly detected in the cancerous tissue of nine different individuals, the result being consistent with well-known profiles of ccRCC. Moreover, this system enabled us to detect the boundaries of cancerous regions based on the expression of TAG. These results strongly suggest that PESI-MS will be applicable to cancer diagnosis, especially when the number of data is augmented.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.