ArticlePediatric nephrology (Berlin, Germany)2012
Hyponatremia may reflect severe inflammation in children with febrile urinary tract infection.
Article in Pediatric nephrology (Berlin, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 42 citations in OpenAlex.
- Electrolyte Imbalance in Young Infants With Febrile UTI: Is It a Marker of Severity?Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Response to: Electrolyte Imbalance in Young Infants With Febrile UTI: Is It a Marker of Severity?Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Construction and validation of a risk prediction model for hyponatremia caused by cervical spinal cord injury.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Kidney involvement during the course of febrile urinary tract infection.Pediatric nephrology (Berlin, Germany) · 2025Review
- A Nomogram for Predicting Surgical Risk in Neonates with Necrotizing Enterocolitis: A Retrospective Cohort Study.Indian journal of pediatrics · 2025Article
- Metabolic acidosis is associated with infection severity in pediatric pyelonephritis and pneumonia.Pediatric nephrology (Berlin, Germany) · 2025Article
- Prediction of urinary tract infection using machine learning methods: a study for finding the most-informative variables.BMC medical informatics and decision making · 2025Article
- Prevalence of and factors associated with Na + /K + imbalances in a population of children hospitalized with febrile urinary tract infection.European journal of pediatrics · 2024Article
- Association between hyponatremia and disease severity in pediatric urinary tract infections.BMC pediatrics · 2024Article
- Relationship of severity of hyponatremia and adverse outcomes in children visiting the emergency department.Frontiers in pediatrics · 2024Article
- Hyponatremia and other potential markers of ultrasound abnormalities after a first febrile urinary tract infection in children.European journal of pediatrics · 2023Article
- Blood analysis for screening of electrolyte and kidney function alterations in patients with febrile urinary tract infection.Acta paediatrica (Oslo, Norway : 1992) · 2023Observational
- Determinants of urinary tract infection in hospitalized patients with acute ischemic stroke.BMC neurology · 2023Article
- [MAS-like lesions and SIADH caused by bortezomib in the treatment of multiple myeloma : three cases report and literature review].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2022Review
- Prevalence, prognostic value, pathophysiology, and management of hyponatraemia in children and adolescents with COVID-19.Acta bio-medica : Atenei Parmensis · 2021Review
- MANAGEMENT OF ENDOCRINE DISEASE: Dysnatraemia in COVID-19: prevalence, prognostic impact, pathophysiology, and management.European journal of endocrinology · 2021Review
- Dysnatremia is a Predictor for Morbidity and Mortality in Hospitalized Patients with COVID-19.The Journal of clinical endocrinology and metabolism · 2021Article
- Hyponatremia in childhood urinary tract infection.European journal of pediatrics · 2021Article
- Case Report: Severe Hyponatremia in Infants With Urinary Tract Infection.Frontiers in pediatrics · 2021Article
- Redefined hyponatremia as a marker to exclude the diagnosis of anastomotic leakage after colorectal cancer surgery.The Journal of international medical research · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHyponatremia is the most common electrolyte abnormality in clinical practice, but little is known about the association between febrile urinary tract infection (UTI) and hyponatremia or its significance to clinical outcomes.
methodsData from 140 children with febrile UTI between 2000 and 2010 were retrospectively analyzed. Laboratory examinations [white blood cell (WBC) count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and serum sodium concentration], renal ultrasonography, (99m)Technetium-dimercaptosuccinic acid (DMSA) scintigraphy, and voiding cystourethrogram were performed. Culture growing >50,000 colonies of one single bacterial species on a urine sample obtained by catheter or >100,000 colonies on two clean-catch samples was required to establish diagnosis of UTI.
resultsIn children with renal cortical defects diagnosed after DMSA scintigraphy (group 1), duration of fever was significantly longer (P = 0.038) and WBC (P = 0.047) and CRP (P < 0.0001) levels significantly higher than in those without renal cortical defects (group 2). However, serum sodium levels were significantly lower in group 1 than group 2 (135.9 ± 2.4 vs 137.4 ± 2.7 mEq/L, P = 0.007). Hyponatremia (serum sodium ≤ 135 mEq/L) was also more frequent in group 1 than in group 2 (74.1 % vs 45.3 %, P = 0.012). Serum sodium concentration was negatively correlated with WBC count (r = -0.156, P = 0.011) and CRP levels (r = -0.160, P= 0.028).
conclusionsOur study indicates that hyponatremia may be a substantial inflammatory marker and is significantly and independently associated with the degree of inflammation in children with febrile UTI.
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