ArticleMedical science monitor : international medical journal of experimental and clinical research2012
Autonomic nervous system activity in constipation-predominant irritable bowel syndrome patients.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Wearable-Based Monitoring of Autonomic and Gastrointestinal Function in Disorders of Gut-Brain Interaction: A Systematic Review and Meta-Analyses.Neurogastroenterology and motility · 2026Pooled it
- Alterations in Heart Rate Variability Associated With Irritable Bowel Syndrome or Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.Clinical and translational gastroenterology · 2020Pooled it
- Gastric Biofeedback in Virtual Reality: Feasibility, Efficacy and Self-Reported Experience.Applied psychophysiology and biofeedback · 2026Trial
- Trial
- Electroacupuncture combined with biofeedback for obstructed defecation syndrome: a retrospective cohort study.International journal of colorectal disease · 2026Article
- Evaluating a mobile-enhanced cognitive behavioral therapy program for university students with irritable bowel syndrome.Internet interventions · 2026Article
- Association between blood lead levels and constipation in adults: insights from NHANES data (2005-2010).BMC gastroenterology · 2025Article
- Review
- Gut bacteria: an etiological agent in human pathological conditions.Frontiers in cellular and infection microbiology · 2024Review
- Heart Rate Variability and Somatization in Adolescents With Irritable Bowel Syndrome.Journal of neurogastroenterology and motility · 2023Article
- Association between constipation and the development of asthma: a meta-analysis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022Article
- Association Between Insomnia and Constipation: A Multicenter Three-year Cross-sectional Study Using Shift Workers' Health Check-up Data.Safety and health at work · 2022Article
- Sleep Deficiency Is Associated With Exacerbation of Symptoms and Impairment of Anorectal and Autonomic Functions in Patients With Functional Constipation.Frontiers in neuroscience · 2022Article
- Sustained ameliorating effects and autonomic mechanisms of transcutaneous electrical acustimulation at ST36 in patients with chronic constipation.Frontiers in neuroscience · 2022Article
- The role of mind body interventions in the treatment of irritable bowel syndrome and fibromyalgia.Frontiers in psychiatry · 2022Review
- Theories behind the effect of starch‑ and sucrose‑reduced diets on gastrointestinal symptoms in irritable bowel syndrome (Review).Molecular medicine reports · 2021Review
- Abnormalities in the thalamo-cortical network in patients with functional constipation.Brain imaging and behavior · 2021Article
- Regulation of the Autonomic Nervous System on Intestine.Frontiers in physiology · 2021Review
- Transcriptomic Signatures Associated With Gray Matter Volume Changes in Patients With Functional Constipation.Frontiers in neuroscience · 2021Article
- A Review of the Complex Relationship between Irritable Bowel Syndrome and Infertility.Medicina (Kaunas, Lithuania) · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe main mechanism underlying irritable bowel syndrome is currently believed to be a dysfunction of the brain-gut axis. Autonomic nervous system dysfunction can contribute to development of irritable bowel syndrome symptoms by disturbing visceral sensations. MATERIAL/
methodsThirty patients with a diagnosis of constipation-predominant irritable bowel syndrome and 30 healthy volunteers were included in the study. Resting and functional autonomic nervous system tests and percutaneous electrogastrography were performed. Plasma adrenalin, noradrenalin, insulin, ghrelin and cholecystokinin activity was analyzed.
resultsIncreased sympathetic activation with disturbed parasympathetic function was demonstrated. Patients had substantially higher plasma catecholamine concentration, which confirms sympathetic overbalance. Hyperinsulinemia may explain sympathetic predominance followed by gastric and intestinal motility deceleration. Abnormal, reduced ghrelin and cholecystokinin titre may disturb brain-gut axis functioning and may be responsible for gastric motility deceleration. In electrogastrography, distinctly lower values of fasting normogastria percentage and dominant power were observed. Patients had substantially lower slow wave coupling percentage both in fasting and postprandial periods, which negatively correlated with plasma catecholamines level. Gastric myoelectrical activity disturbances may result from lack of sympatho-parasympathetic equilibrium.
conclusionsCentral sympathetic influence within the brain-gut axis is most probably responsible for myoelectrical activity disturbances in irritable bowel syndrome patients.
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Registered trials
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