ArticleDiabetologia2012
Elevated NEFA levels impair glucose effectiveness by increasing net hepatic glycogenolysis.
Article in Diabetologia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
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- 14-Day Ketone Supplementation Lowers Glucose and Improves Vascular Function in Obesity: A Randomized Crossover Trial.The Journal of clinical endocrinology and metabolism · 2021Trial
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- Comparative Metabolomic Profiling of L-Histidine and NEFA Treatments in Bovine Mammary Epithelial Cells.Animals : an open access journal from MDPI · 2024Article
- Meta-Inflammation and De Novo Lipogenesis Markers Are Involved in Metabolic Associated Fatty Liver Disease Progression in BTBR ob/ob Mice.International journal of molecular sciences · 2022Article
- Chromatographic fractions fromJournal of traditional and complementary medicine · 2021Article
- Plasma Epinephrine Contributes to the Development of Experimental Hypoglycemia-Associated Autonomic Failure.The Journal of clinical endocrinology and metabolism · 2020Article
- Diabetic‑induced alterations in hepatic glucose and lipid metabolism: The role of type 1 and type 2 diabetes mellitus (Review).Molecular medicine reports · 2020Review
- Passive exposure to heat improves glucose metabolism in overweight humans.Acta physiologica (Oxford, England) · 2020Article
- Effects of growth hormone on hepatic insulin sensitivity and glucose effectiveness in healthy older adults.Endocrine · 2019Article
- Association of NEFA composition with insulin sensitivity and beta cell function in the Prospective Metabolism and Islet Cell Evaluation (PROMISE) cohort.Diabetologia · 2018Article
- Investigation into Hypoglycemic, Antihyperlipidemic, and Renoprotective Potentials ofBioMed research international · 2017Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
aims/hypothesisAcute hyperglycaemia rapidly suppresses endogenous glucose production (EGP) in non-diabetic individuals, mainly by inhibiting glycogenolysis. Loss of this 'glucose effectiveness' contributes to fasting hyperglycaemia in type 2 diabetes. Elevated NEFA levels characteristic of type 2 diabetes impair glucose effectiveness, although the mechanism is not fully understood. Therefore we examined the impact of increasing NEFA levels on the ability of hyperglycaemia to regulate pathways of EGP.
methodsWe performed 4 h 'pancreatic clamp' studies (somatostatin; basal glucagon/growth hormone/insulin) in seven non-diabetic individuals. Glucose fluxes (D-[6,6-(2)H(2)]glucose) and hepatic glycogen concentrations ((13)C magnetic resonance spectroscopy) were quantified under three conditions: euglycaemia, hyperglycaemia and hyperglycaemia with elevated NEFA (HY-NEFA).
resultsEGP was suppressed by hyperglycaemia, but not by HY-NEFA. Hepatic glycogen concentration decreased ~14% with prolonged fasting during euglycaemia and increased by ~12% with hyperglycaemia. In contrast, raising NEFA levels in HY-NEFA caused a substantial ~23% reduction in hepatic glycogen concentration. Moreover, rates of gluconeogenesis were decreased with hyperglycaemia, but increased with HY-NEFA. CONCLUSIONS/
interpretationIncreased NEFA appear to profoundly blunt the ability of hyperglycaemia to inhibit net glycogenolysis under basal hormonal conditions.
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