Evidence map›Paper›PMID 22846849›Full record

ArticleBehavioural brain research2013

The development of face orienting mechanisms in infants at-risk for autism.

Mayada Elsabbagh, Teodora Gliga, Andrew Pickles, Kristelle Hudry, Tony Charman, Mark H Johnson, BASIS Team

Open access · hybridAbstract read
In one paragraph

Article in Behavioural brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 2 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 2 syntheses or guidelines pooled it, 256 citations in OpenAlex.

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  12. Narrative Ability in Autism and First-Degree Relatives.Journal of autism and developmental disorders · 2025
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38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Mayada ElsabbaghDepartment of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, QC, H3A 1A1, Canada. mayada.elsabbagh@mcgill.ca
Teodora Gliga
Andrew Pickles
Kristelle Hudry
Tony Charman
Mark H Johnson
BASIS Team
Birkbeck, University of London · GBKing's College London · GBLa Trobe University · AUMcGill University · CA

Funding

Department of Health NF-SI-0510-10268Medical Research Council G0701484
6 · The paper itself

Abstract

A popular idea related to early brain development in autism is that a lack of attention to, or interest in, social stimuli early in life interferes with the emergence of social brain networks mediating the typical development of socio-communicative skills. Compelling as it is, this developmental account has proved difficult to verify empirically because autism is typically diagnosed in toddlerhood, after this process of brain specialization is well underway. Using a prospective study, we directly tested the integrity of social orienting mechanisms in infants at-risk for autism by virtue of having an older diagnosed sibling. Contrary to previous accounts, infants who later develop autism exhibit a clear orienting response to faces that are embedded within an array of distractors. Nevertheless, infants at-risk for autism as a group, and irrespective of their subsequent outcomes, had a greater tendency to select and sustain attention to faces. This pattern suggests that interactions among multiple social and attentional brain systems over the first two years give rise to variable pathways in infants at-risk.

Indexed as

Child DevelopmentOrientationSocial BehaviorAttentionAutistic DisorderChild, PreschoolFemaleHumansInfantInfant BehaviorMaleNeuropsychological TestsProspective StudiesRisk FactorsSiblingsSocial PerceptionAt-riskAttentionAutismFace-processingInfancyProspective study

Identifiers

PMID22846849
PMCPMC3730054
OpenAlexW2097423599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.