ArticleBMC genomics2012
Pleiotropic functions of catabolite control protein CcpA in Butanol-producing Clostridium acetobutylicum.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 69 citations in OpenAlex.
- Construction of an engineered Escherichia coli strain with enhanced intestinal colonization and anti-inflammatory efficacy in colitis.Cellular & molecular immunology · 2026Article
- Alleviation of Carbon Catabolite Repression throughApplied and environmental microbiology · 2023Article
- Co‑cultivation of anaerobic fungi with Clostridium acetobutylicum bolsters butyrate and butanol production from cellulose and lignocellulose.Journal of industrial microbiology & biotechnology · 2023Article
- Functional dissection and modulation of the BirA protein for improved autotrophic growth of gas-fermenting Clostridium ljungdahlii.Microbial biotechnology · 2021Article
- Enforcing ATP hydrolysis enhanced anaerobic glycolysis and promoted solvent production in Clostridium acetobutylicum.Microbial cell factories · 2021Article
- Sporulation in solventogenic and acetogenic clostridia.Applied microbiology and biotechnology · 2021Review
- Ribozyme-Mediated Downregulation Uncovers DNA Integrity Scanning Protein A (DisA) as a Solventogenesis Determinant inFrontiers in bioengineering and biotechnology · 2021Article
- Article
- The Small RNA sr8384 Is a Crucial Regulator of Cell Growth in Solventogenic Clostridia.Applied and environmental microbiology · 2020Article
- RRNPP-type quorum sensing affects solvent formation and sporulation inMicrobiology (Reading, England) · 2020Article
- GlnR Negatively Regulates Glutamate-Dependent Acid Resistance in Lactobacillus brevis.Applied and environmental microbiology · 2020Article
- A Novel Dual-Applied and environmental microbiology · 2018Article
- Enhanced Production of Polymyxin E inBioMed research international · 2018Article
- The industrial anaerobe Clostridium acetobutylicum uses polyketides to regulate cellular differentiation.Nature communications · 2017Article
- Article
- Microbial solvent formation revisited by comparative genome analysis.Biotechnology for biofuels · 2017Article
- Sugar uptake by the solventogenic clostridia.World journal of microbiology & biotechnology · 2016Article
- RNA Sequencing Reveals Xyr1 as a Transcription Factor Regulating Gene Expression beyond Carbohydrate Metabolism.BioMed research international · 2016Article
- NanI Sialidase, CcpA, and CodY Work Together To Regulate Epsilon Toxin Production by Clostridium perfringens Type D Strain CN3718.Journal of bacteriology · 2015Article
- Investigation into the role of catabolite control protein A in the metabolic regulation ofExperimental and therapeutic medicine · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClostridium acetobutylicum has been used to produce butanol in industry. Catabolite control protein A (CcpA), known to mediate carbon catabolite repression (CCR) in low GC gram-positive bacteria, has been identified and characterized in C. acetobutylicum by our previous work (Ren, C. et al. 2010, Metab Eng 12:446-54). To further dissect its regulatory function in C. acetobutylicum, CcpA was investigated using DNA microarray followed by phenotypic, genetic and biochemical validation.
resultsCcpA controls not only genes in carbon metabolism, but also those genes in solvent production and sporulation of the life cycle in C. acetobutylicum: i) CcpA directly repressed transcription of genes related to transport and metabolism of non-preferred carbon sources such as d-xylose and l-arabinose, and activated expression of genes responsible for d-glucose PTS system; ii) CcpA is involved in positive regulation of the key solventogenic operon sol (adhE1-ctfA-ctfB) and negative regulation of acidogenic gene bukII; and iii) transcriptional alterations were observed for several sporulation-related genes upon ccpA inactivation, which may account for the lower sporulation efficiency in the mutant, suggesting CcpA may be necessary for efficient sporulation of C. acetobutylicum, an important trait adversely affecting the solvent productivity.
conclusionsThis study provided insights to the pleiotropic functions that CcpA displayed in butanol-producing C. acetobutylicum. The information could be valuable for further dissecting its pleiotropic regulatory mechanism in C. acetobutylicum, and for genetic modification in order to obtain more effective butanol-producing Clostridium strains.
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