ArticleGenes, brain, and behavior2012
High-throughput phenotyping of avoidance learning in mice discriminates different genotypes and identifies a novel gene.
Article in Genes, brain, and behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of the development and application of home cage monitoring in laboratory mice and rats.BMC biology · 2023Pooled it
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- Neuronal Necroptosis Drives Neuroinflammation and Cognitive Decline Independent of Neuronal Cell Death.Aging and disease · 2025Article
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- ReptiLearn: An automated home cage system for behavioral experiments in reptiles without human intervention.PLoS biology · 2024Article
- Increased burden of rare protein-truncating variants in constrained, brain-specific and synaptic genes in extremely impulsively violent males with antisocial personality disorder.Genes, brain, and behavior · 2024Article
- Brain Expression of CPB2 and Effects of Cpb2 Deficiency in Mouse Models of Behavior.Thrombosis and haemostasis · 2024Article
- Challenges and advanced concepts for the assessment of learning and memory function in mice.Frontiers in behavioral neuroscience · 2023Review
- Selective Ablation ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Integrated Multi-Omics Analysis Reveals the Effect of Maternal Gestational Diabetes on Fetal Mouse Hippocampi.Frontiers in cell and developmental biology · 2022Article
- Long-Term Effects of Low-Intensity Blast Non-Inertial Brain Injury on Anxiety-Like Behaviors in Mice: Home-Cage Monitoring Assessments.Neurotrauma reports · 2022Article
- Measuring Behavior in the Home Cage: Study Design, Applications, Challenges, and Perspectives.Frontiers in behavioral neuroscience · 2021Article
- Learning Set Formation and Reversal Learning in Mice During High-Throughput Home-Cage-Based Olfactory Discrimination.Frontiers in behavioral neuroscience · 2021Article
- Deep learning-based behavioral analysis reaches human accuracy and is capable of outperforming commercial solutions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
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- Lack of anticipatory behavior in Gpr88 knockout mice showed by automatized home cage phenotyping.Genes, brain, and behavior · 2018Article
- Protein instability, haploinsufficiency, and cortical hyper-excitability underlie STXBP1 encephalopathy.Brain : a journal of neurology · 2018Article
- Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice.GeroScience · 2018Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Recognizing and avoiding aversive situations are central aspects of mammalian cognition. These abilities are essential for health and survival and are expected to have a prominent genetic basis. We modeled these abilities in eight common mouse inbred strains covering ∼75% of the species' natural variation and in gene-trap mice (>2000 mice), using an unsupervised, automated assay with an instrumented home cage (PhenoTyper) containing a shelter with two entrances. Mice visited this shelter for 20-1200 times/24 h and 71% of all mice developed a significant and often strong preference for one entrance. Subsequently, a mild aversive stimulus (shelter illumination) was automatically delivered when mice used their preferred entrance. Different genotypes developed different coping strategies. Firstly, the number of entries via the preferred entrance decreased in DBA/2J, C57BL/6J and 129S1/SvImJ, indicating that these genotypes associated one specific entrance with the aversive stimulus. Secondly, mice started sleeping outside (C57BL/6J, DBA/2J), indicating they associated the shelter, in general, with the aversive stimulus. Some mice showed no evidence for an association between the entrance and the aversive light, but did show markedly shorter shelter residence times in response to illumination, indicating they did perceive illumination as aversive. Finally, using this assay, we screened 43 different mutants, which yielded a novel gene, specc1/cytospinB. This mutant showed profound and specific delay in avoidance learning. Together, these data suggest that different genotypes express distinct learning and/or memory of associations between shelter entrance and aversive stimuli, and that specc1/cytospinB is involved in this aspect of cognition.
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