ArticleMicrocirculation (New York, N.Y. : 1994)2012
Cerebral microcirculatory responses of insulin-resistant rats are preserved to physiological and pharmacological stimuli.
Article in Microcirculation (New York, N.Y. : 1994), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Cerebral hemodynamics in obesity: relationship with sex, age, and adipokines in a cohort-based study.GeroScience · 2021Article
- Effects of prolonged type 2 diabetes on mitochondrial function in cerebral blood vessels.American journal of physiology. Heart and circulatory physiology · 2019Article
- Impact of Metabolic Diseases on Cerebral Circulation: Structural and Functional Consequences.Comprehensive Physiology · 2018Review
- Impaired Mitochondrial Respiration in Large Cerebral Arteries of Rats with Type 2 Diabetes.Journal of vascular research · 2017Article
- The mitochondrial function of the cerebral vasculature in insulin-resistant Zucker obese rats.American journal of physiology. Heart and circulatory physiology · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivePreviously, we have shown that IR impairs the vascular reactivity of the major cerebral arteries of ZO rats prior to the occurrence of Type-II diabetes mellitus. However, the functional state of the microcirculation in the cerebral cortex is still being explored.
methodsWe tested the local CoBF responses of 11-13-week-old ZO (n = 31) and control ZL (n = 32) rats to several stimuli measured by LDF using a closed cranial window setup.
resultsThe topical application of 1-100 μm bradykinin elicited the same degree of CoBF elevation in both ZL and ZO groups. There was no significant difference in the incidence, latency, and amplitude of the NMDA-induced CSD-related hyperemia between the ZO and ZL groups. Hypercapnic CoBF response to 5% carbon-dioxide ventilation did not significantly change in the ZO compared with the ZL. Topical bicuculline-induced cortical seizure was accompanied by the same increase of CoBF in both the ZO and ZL at all bicuculline doses.
conclusionsCoBF responses of the microcirculation are preserved in the early period of the metabolic syndrome, which creates an opportunity for intervention to prevent and restore the function of the major cerebral vascular beds.
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Registered trials
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