ArticleISRN gastroenterology2012
Current trends in the management of gastroesophageal reflux disease: a review.
Article in ISRN gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02274636 (Study of a Dietary Supplement for Reflux During Sleep), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of a Dietary Supplement for Reflux During Sleep
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
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- Dexlansoprazole for Heartburn Relief in Adolescents with Symptomatic, Nonerosive Gastro-esophageal Reflux Disease.Digestive diseases and sciences · 2017Trial
- Treatment of gastroesophageal reflux disease using radiofrequency ablation (Stretta procedure): An interim analysis of a randomized trial.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2017Trial
- Association of healthy lifestyle behaviors with incident gastroesophageal reflux disease in a large population-based prospective cohort.Preventive medicine reports · 2025Article
- E-GastryalJournal of clinical medicine · 2025Article
- Clinical manifestations of gastrointestinal diseases in the oral cavity.The Saudi dental journal · 2021Review
- Etiological Analysis of Reactive Gastropathy in an Urban Population.Gastrointestinal tumors · 2021Article
- Investigating rates of reoperation or postsurgical gastroparesis following fundoplication or paraesophageal hernia repair in New York State.Surgical endoscopy · 2019Article
- Evidence-Based Practice Guideline for Surgical Treatment of Gastroesophageal Reflux Disease 2018.Journal of gastric cancer · 2018Review
- Dietary habits and obesity indices in patients with gastro-esophageal reflux disease: a comparative cross-sectional study.BMC gastroenterology · 2017Article
- Fewer acute respiratory infection episodes among patients receiving treatment for gastroesophageal reflux disease.PloS one · 2017Article
- The importance of the mesh shape in preventing recurrence after Nissen fundoplication.International journal of clinical and experimental medicine · 2015Article
- Minimal endoscopic changes in non-erosive reflux disease.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2015Article
- Can yoga be used to treat gastroesophageal reflux disease?International journal of yoga · 2013Article
- Gastroesophageal reflux and rhinosinusitis.Current allergy and asthma reports · 2013Review
- Gastroesophageal reflux in critically ill children: a review.ISRN gastroenterology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastroesophageal reflux disease (GERD) is a chronic disorder of the upper gastrointestinal tract with global distribution. The incidence is on the increase in different parts of the world. In the last 30 to 40 years, research findings have given rise to a more robust understanding of its pathophysiology, clinical presentation, and management. The current definition of GERD (The Montreal definition, 2006) is not only symptom-based and patient-driven, but also encompasses esophageal and extraesophageal manifestations of the disease. The implication is that the disease can be confidently diagnosed based on symptoms alone. Nonerosive reflux disease (NERD) remains the predominant form of GERD. Current thinking is that NERD and erosive reflux disease (ERD) are distinct phenotypes of GERD rather than the old concept which regarded them as components of a disease spectrum. Non erosive reflux disease is a very heterogeneous group with significant overlap with other functional gastrointestinal disorders. There is no gold standard for the diagnosis of GERD. Esophageal pH monitoring and intraluminal impedance monitoring have thrown some light on the heterogeneity of NERD. A substantial proportion of GERD patients continue to have symptoms despite optimal PPI therapy, and this has necessitated research into the development of new drugs. Several safety concerns have been raised about chronic use of proton pump inhibitors but these are yet to be substantiated in controlled studies. The debate about efficacy of long-term medical treatment compared to surgery continues, however, recent data indicate that modern surgical techniques and long-term PPI therapy have comparable efficacy. These and other issues are subjects of further research.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.