ArticlePloS one2012
A role for mesenchyme dynamics in mouse lung branching morphogenesis.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Svep1 orchestrates distal airway patterning and alveolar differentiation in murine lung development.eLife · 2026Article
- Insight into the pathogenesis of interstitial lung diseases and near-to-native lung fibrosis models.European journal of medical research · 2025Review
- Hedgehog Signaling Pathway Orchestrates Human Lung Branching Morphogenesis.International journal of molecular sciences · 2022Article
- Application of 3D MAPs pipeline identifies the morphological sequence chondrocytes undergo and the regulatory role of GDF5 in this process.Nature communications · 2021Article
- The biomechanical basis of biased epithelial tube elongation in lung and kidney development.Development (Cambridge, England) · 2021Article
- Organ-Specific Branching Morphogenesis.Frontiers in cell and developmental biology · 2021Review
- The Lung Vasculature: A Driver or Passenger in Lung Branching Morphogenesis?Frontiers in cell and developmental biology · 2020Review
- Fgf10/Fgfr2b Signaling Orchestrates the Symphony of Molecular, Cellular, and Physical Processes Required for Harmonious Airway Branching Morphogenesis.Frontiers in cell and developmental biology · 2020Review
- Comprehensive anatomic ontologies for lung development: A comparison of alveolar formation and maturation within mouse and human lung.Journal of biomedical semantics · 2019Article
- Deconstructing the principles of ductal network formation in the pancreas.PLoS biology · 2018Article
- Human lung branching morphogenesis is orchestrated by the spatiotemporal distribution of ACTA2, SOX2, and SOX9.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Mathematical Approaches of Branching Morphogenesis.Frontiers in genetics · 2018Review
- Computational models of airway branching morphogenesis.Seminars in cell & developmental biology · 2017Review
- Quantifying stretch and secretion in the embryonic lung: Implications for morphogenesis.Mechanisms of development · 2015Article
- Developmental Programming of Branching Morphogenesis in the Kidney.Journal of the American Society of Nephrology : JASN · 2015Article
- Development of Lung Epithelium from Induced Pluripotent Stem Cells.Current transplantation reports · 2015Article
- In vitro reconstruction of branched tubular structures from lung epithelial cells in high cell concentration gradient environment.Scientific reports · 2015Article
- Review
- Quantitative approaches to uncover physical mechanisms of tissue morphogenesis.Current opinion in biotechnology · 2013Review
- The control of branching morphogenesis.Open biology · 2013Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian airways are highly ramified tree-like structures that develop by the repetitive branching of the lung epithelium into the surrounding mesenchyme through reciprocal interactions. Based on a morphometric analysis of the epithelial tree, it has been recently proposed that the complete branching scheme is specified early in each lineage by a programme using elementary patterning routines at specific sites and times in the developing lung. However, the coupled dynamics of both the epithelium and mesenchyme have been overlooked in this process. Using a qualitative and quantitative in vivo morphometric analysis of the E11.25 to E13.5 mouse whole right cranial lobe structure, we show that beyond the first generations, the branching stereotypy relaxes and both spatial and temporal variations are common. The branching pattern and branching rate are sensitive to the dynamic changes of the mesoderm shape that is in turn mainly dependent upon the volume and shape of the surrounding intrathoracic organs. Spatial and temporal variations of the tree architecture are related to local and subtle modifications of the mesoderm growth. Remarkably, buds never meet after suffering branching variations and continue to homogenously fill the opening spaces in the mesenchyme. Moreover despite inter-specimen variations, the growth of the epithelial tree and the mesenchyme remains highly correlated over time at the whole lobe level, implying a long-range regulation of the lung lobe morphogenesis. Together, these findings indicate that the lung epithelial tree is likely to adapt in real time to fill the available space in the mesenchyme, rather than being rigidly specified and predefined by a global programme. Our results strongly support the idea that a comprehensive understanding of lung branching mechanisms cannot be inferred from the branching pattern or behavior alone. Rather it needs to be elaborated upon with the reconsideration of mesenchyme-epithelium coupled growth and lung tissues mechanics.
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