ArticlePloS one2012
Atrophic cardiac remodeling induced by taurine deficiency in Wistar rats.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- A Systematic Risk Assessment and Meta-Analysis on the Use of Oral β-Alanine Supplementation.Advances in nutrition (Bethesda, Md.) · 2019Pooled it
- Intravenously delivered multilineage-differentiating stress-enduring cells dampen hyperoxia-induced lung injury in a rat model with features of bronchopulmonary dysplasia.Stem cell research & therapy · 2026Article
- Carnosine-Related Metabolism in Rat Cardiomyocytes and Human Heart Tissue.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Metabolic changes contribute to maladaptive right ventricular hypertrophy in pulmonary hypertension beyond pressure overload: an integrative imaging and omics investigation.Basic research in cardiology · 2024Article
- Beta-alanine promotes angiogenesis in laser-induced choroidal neovascularization mice models.International journal of ophthalmology · 2024Article
- Review
- Physiological Roles of Carnosine in Myocardial Function and Health.Advances in nutrition (Bethesda, Md.) · 2022Review
- Intracellular taurine deficiency impairs cardiac contractility in rainbow trout (Oncorhynchus mykiss) without affecting aerobic performance.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2022Article
- Sulfur-containing amino acids and their metabolites in atrial fibrosis.Frontiers in pharmacology · 2022Review
- The Role of Taurine in Mitochondria Health: More Than Just an Antioxidant.Molecules (Basel, Switzerland) · 2021Review
- Small dedifferentiated cardiomyocytes bordering on microdomains of fibrosis: evidence for reverse remodeling with assisted recovery.Journal of cardiovascular pharmacology · 2014Article
- Taurine rescues cisplatin-induced muscle atrophy in vitro: a morphological study.Oxidative medicine and cellular longevity · 2014Article
- Atrophic cardiomyocyte signaling in hypertensive heart disease.Journal of cardiovascular pharmacology · 2013Article
- Protective Effect of Taurine on Mice with Doxorubicin-induced Acute Kidney Injury.Advances in experimental medicine and biologyArticle
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMicronutrient deficiency is observed in heart failure patients. Taurine, for example, represents 50% of total free amino acids in the heart, and in vivo studies have linked taurine deficiency with cardiomyopathy.
methodsThirty-four male Wistar rats (body weight = 100 g) were weighed and randomly assigned to one of two groups: Control (C) or taurine-deficient (T (-)). Beta-alanine at a concentration of 3% was added to the animals' water to induce taurine deficiency in the T (-) group. On day 30, the rats were individually submitted to echocardiography; morphometrical and histopathological evaluation and metalloproteinase activity, oxidative stress and inflammation evaluation were performed. Tissue samples were collected to determine the taurine concentration in the heart.
resultsTaurine deficiency led to decreases in: ventricular wall thickness, left ventricle dry weight, myocyte sectional area, left ventricle posterior wall thickness and ventricular geometry. With regard to heart function, the velocity of the A wave, the ratio between the E and A wave, the ejection fraction, fractional shortening and cardiac output values were decreased in T (-) rats, suggesting abnormal diastolic and systolic function. Increased fibrosis, inflammation and increased activation of metalloproteinases were not observed. Oxidative stress was increased in deficient animals.
conclusionsThese data suggest that taurine deficiency promotes structural and functional cardiac alterations with unique characteristics.
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