ArticleClinical & developmental immunology2012
Interactions of miR-34b/c and TP53 polymorphisms on the risk of intracranial aneurysm.
Article in Clinical & developmental immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- An rs4705342 T>C polymorphism in the promoter of miR-143/145 is associated with a decreased risk of ischemic stroke.Scientific reports · 2016Trial
- A two-miRNA signature (miR-21 and miR-92) in peripheral whole blood as a potential biomarker for diagnosis of human cerebral aneurysms.Archives of medical science : AMS · 2024Article
- The roles and diagnostic value of miRNA-1246 in the serum of patients with intracranial aneurysms.Translational neuroscience · 2022Article
- Shedding the Light on the Natural History of Intracranial Aneurysms: An Updated Overview.Medicina (Kaunas, Lithuania) · 2021Review
- Morphological parameters of middle cerebral arteries associated with aneurysm formation.Neuroradiology · 2021Article
- Identification of key genes and pathways in abdominal aortic aneurysm by integrated bioinformatics analysis.The Journal of international medical research · 2020Article
- LncRNA TUG1 alleviates sepsis-induced acute lung injury by targeting miR-34b-5p/GAB1.BMC pulmonary medicine · 2020Article
- Association of miR-34b/c rs4938723 and TP53 Arg72Pro Polymorphisms with Neuroblastoma Susceptibility: Evidence from Seven Centers.Translational oncology · 2019Article
- Association of Common Genetic Variants in Pre-microRNAs and Neuroblastoma Susceptibility: A Two-Center Study in Chinese Children.Molecular therapy. Nucleic acids · 2018Article
- Association Between Genetic Variant in the Promoter of Pri-miR-34b/c and Risk of Glioma.Frontiers in oncology · 2018Article
- Association between functional polymorphisms in the promoter of the miR-143/145 cluster and risk of intracranial aneurysm.Scientific reports · 2017Article
- Toward Understanding Non-coding RNA Roles in Intracranial Aneurysms and Subarachnoid Hemorrhage.Translational neuroscience · 2017Article
- Combined analysis of pri-miR-34b/c rs4938723 and TP53 Arg72Pro with cervical cancer risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Apolipoprotein E polymorphism and the risk of intracranial aneurysms in a Chinese population.BMC neurology · 2016Article
- A Potential Polymorphism in the Promoter of Let-7 is Associated With an Increased Risk of Intracranial Aneurysm: A Case-Control Study.Medicine · 2015Observational
- RNA-Sequencing Analysis of Messenger RNA/MicroRNA in a Rabbit Aneurysm Model Identifies Pathways and Genes of Interest.AJNR. American journal of neuroradiology · 2015Article
- Promoter polymorphisms of miR-34b/c are associated with risk of gastric cancer in a Chinese population.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Interactions of miR-34b/c and TP-53 polymorphisms on the risk of nasopharyngeal carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- Genetic associations of intracranial aneurysm formation and sub-arachnoid hemorrhage.Asian journal of neurosurgeryReview
- Genetic factors involves in intracranial aneurysms--actualities.Journal of medicine and lifeReview
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several lines of evidence indicate that inflammatory processes play a key role in the happening and development of intracranial aneurysm (IA). Recently, polymorphisms in the TP53 gene were shown to be associated with inflammation and inflammatory disease. The aim of this study was to investigate the interactions of miR-34b/c and TP53 Arg72-Pro polymorphisms on the risk of IA in a Chinese population. A total of 590 individuals (including 164 patients with IA and 426 controls) were involved in this study. The polymorphisms (i.e., miR-34b/c rs4938723 and TP53 Arg72-Pro) were genotyped by polymerase chain reaction-restriction fragment length polymorphism assay and DNA sequencing. We found that the CC genotype of miR-34b/c rs4938723 was significantly associated with a decreased risk of IA compared with the TT genotype. Moreover, a significant gene interaction of the carriers with the combined genotypes of miR-34b/c rs4938723CC and TP53 Arg72Pro CG/CC/GG had a decreased risk of IA, compared with those carrying miR-34b/c rs4938723CT/TT+TP53 Arg72Pro GG/CG/CC combined genotypes. These findings suggest that the miR-34b/c rs4938723CC and TP53 Arg72-Pro polymorphisms may be involved in the susceptibility to IA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.