Evidence map›Paper›PMID 22844274›Full record

ArticleGastroenterology research and practice2012

Comparison of Tissue Architectural Changes between Radiofrequency Ablation and Cryospray Ablation in Barrett's Esophagus Using Endoscopic Three-Dimensional Optical Coherence Tomography.

Tsung-Han Tsai, Chao Zhou, Hsiang-Chieh Lee, Yuankai K Tao, Osman O Ahsen, Marisa Figueiredo, Desmond C Adler, Joseph M Schmitt, Qin Huang, James G Fujimoto and 1 more

Open access · goldAbstract read
In one paragraph

Article in Gastroenterology research and practice, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Application of optical coherence tomography in clinical diagnosis.Journal of X-ray science and technology · 2019
    Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Evaluation of Barrett esophagus by multiphoton microscopy.Archives of pathology & laboratory medicine · 2014
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Tsung-Han TsaiDepartment of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Chao Zhou
Hsiang-Chieh Lee
Yuankai K Tao
Osman O Ahsen
Marisa Figueiredo
Desmond C Adler
Joseph M Schmitt
Qin Huang
James G Fujimoto
Hiroshi Mashimo
Massachusetts Institute of Technology · USHarvard University · USSt. Jude Medical Center · USVA Boston Healthcare System · US

Funding

OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHYR01CA075289 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FUJIMOTO, JAMES G, MASHIMO, HIROSHI · 1997 to 2018
$4.8M
Ultrahigh speed and resolution OCT/OCM using broadband swept VCSEL technologyR44CA101067 · NCI · PRAEVIUM RESEARCH, INC. · PI JAYARAMAN, VIJAYSEKHAR · 2003 to 2012
$2.9M
Integrated Optical Coherence Tomography and Microscopy for Molecular-Targeted ImaR00EB010071 · NIBIB · LEHIGH UNIVERSITY · PI ZHOU, CHAO · 2012 to 2013
$479k
Integrated Optical Coherence Tomography and Microscopy for Molecular-Targeted ImaK99EB010071 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ZHOU, CHAO · 2011 to 2011
$90k
NCI NIH HHS R01 CA075289NCI NIH HHS R44 CA101067NIBIB NIH HHS K99 EB010071
6 · The paper itself

Abstract

Two main nonsurgical endoscopic approaches for ablating dysplastic and early cancer lesions in the esophagus have gained popularity, namely, radiofrequency ablation (RFA) and cryospray ablation (CSA). We report a uniquely suited endoscopic and near-microscopic imaging modality, three-dimensional (3D) optical coherence tomography (OCT), to assess and compare the esophagus immediately after RFA and CSA. The maximum depths of architectural changes were measured and compared between the two treatment groups. RFA was observed to induce 230~260 μm depth of architectural changes after each set of ablations over a particular region, while CSA was observed to induce edema-like spongiform changes to ~640 μm depth within the ablated field. The ability to obtain micron-scale depth-resolved images of tissue structural changes following different ablation therapies makes 3D-OCT an ideal tool to assess treatment efficacy. Such information could be potentially used to provide real-time feedback for treatment dosing and to identify regions that need further retreatment.

Identifiers

PMID22844274
PMCPMC3400425
OpenAlexW1496316790

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.