ArticleAdvanced functional materials2011
Multifunctionalized electrospun silk fibers promote axon regeneration in central nervous system.
Article in Advanced functional materials, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 70 citations in OpenAlex.
- Smart hydrogel systems for skin fibrosis: rational design, mechanisms and therapeutic applications.Regenerative biomaterials · 2026Review
- Bioengineering strategy to promote CNS nerve growth and regeneration via chronic glutamate signaling.Acta biomaterialia · 2024Article
- Silk-based conductive materials for smart biointerfaces.Smart medicine · 2023Review
- Co-Delivery of Docosahexaenoic Acid and Brain-Derived Neurotropic Factor from Electrospun Aligned Core-Shell Fibrous Membranes in Treatment of Spinal Cord Injury.Pharmaceutics · 2022Article
- Anisotropic scaffolds for peripheral nerve and spinal cord regeneration.Bioactive materials · 2021Review
- An Insulin-like Growth Factor-1 ConjugatedPharmaceutics · 2021Article
- Biopolymer Nanofibers for Nanogenerator Development.Research (Washington, D.C.) · 2021Review
- Polymeric Fibers as Scaffolds for Spinal Cord Injury: A Systematic Review.Frontiers in bioengineering and biotechnology · 2021Review
- Silk fibroins in multiscale dimensions for diverse applications.RSC advances · 2020Review
- Heparinized silk fibroin hydrogels loading FGF1 promote the wound healing in rats with full-thickness skin excision.Biomedical engineering online · 2019Article
- Identification and applications of neuroactive silk proteins: a narrative review.Journal of applied biomedicine · 2019Review
- Recent advances in nanotherapeutic strategies for spinal cord injury repair.Advanced drug delivery reviews · 2019Review
- Development of Oxidized Polyvinyl Alcohol-Based Nerve Conduits Coupled with the Ciliary Neurotrophic Factor.Materials (Basel, Switzerland) · 2019Article
- Carbon-Fiber Based Microelectrode Array Embedded with a Biodegradable Silk Support for In Vivo Neural Recording.Journal of Korean medical science · 2019Article
- Silkworm silk-based materials and devices generated using bio-nanotechnology.Chemical Society reviews · 2018Review
- Bombyx mori Silk Fibroin Scaffolds with Antheraea pernyi Silk Fibroin Micro/Nano Fibers for Promoting EA. hy926 Cell Proliferation.Materials (Basel, Switzerland) · 2017Article
- Developing Extracellular Matrix Technology to Treat Retinal or Optic Nerve Injury(1,2,3).eNeuro · 2015Review
- Nanofiber-mediated release of retinoic acid and brain-derived neurotrophic factor for enhanced neuronal differentiation of neural progenitor cells.Drug delivery and translational research · 2015Article
- Strategies for regeneration of components of nervous system: scaffolds, cells and biomolecules.Regenerative biomaterials · 2015Review
- Use of Mesothelial Cells and Biological Matrices for Tissue Engineering of Simple Epithelium Surrogates.Frontiers in bioengineering and biotechnology · 2015Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
The repair of central nerves remains a major challenge in regenerative neurobiology. Regenerative guides possessing critical features such as cell adhesion, physical guiding and topical stimulation are needed. To generate such a guide, silk protein materials are prepared using electrospinning. The silk is selected for this study due to its biocompatibility and ability to be electrospun for the formation of aligned biofunctional nanofibers. The addition of Brain Derived Neurotrophic Factor (BDNF), Ciliary Neurotrophic Factor (CNTF) or both to the electrospun fibers enable enhanced function without impact to the structure or the surface morphology. Only a small fraction of the loaded growth factors is released over time allowing the fibers to continue to provide these factors to the cells for extended periods of time. The entrapped factors remain active and available to the cells as rat retinal ganglion cells (RGCs) exhibit longer axonal growth when in contact with the biofunctionalized fibers. Compare to non-functionalized fibers, the growth of neurites increased 2 fold on fibers containing BDNF, 2.5 fold with fibers containing CNTF and by almost 3-fold on fibers containing both factors. The results demonstrate the potential of aligned and functionalized electrospun silk fibers to promote nerve growth in the central nervous system, underlying the great potential of complex biomaterials in neuroregenerative strategies following axotomy and nerve crush traumas.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.