ArticlePLoS genetics2012
F-box protein specificity for g1 cyclins is dictated by subcellular localization.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 47 citations in OpenAlex.
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- Induced proximity-based therapeutic modalities.Nature reviews. Drug discovery · 2026Review
- Evidence for novel mechanisms that control cell-cycle entry and cell size.Molecular biology of the cell · 2024Article
- Hyperactive Ras disrupts cell size control and a key step in cell cycle entry in budding yeast.Genetics · 2023Article
- Identification of Deubiquitinase Substrates in Saccharomyces cerevisiae by Systematic Overexpression.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Repression of essential cell cycle genes increases cellular fitness.PLoS genetics · 2022Article
- Mad3 modulates the GScience advances · 2022Article
- The rice EP3 and OsFBK1 E3 ligases alter plant architecture and flower development, and affect transcript accumulation of microRNA pathway genes and their targets.Plant biotechnology journal · 2022Article
- Ubc1 turnover contributes to the spindle assembly checkpoint in Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2021Article
- Article
- Protein Homeostasis Networks and the Use of Yeast to Guide Interventions in Alzheimer's Disease.International journal of molecular sciences · 2020Review
- Regulation of cell cycle drivers by Cullin-RING ubiquitin ligases.Experimental & molecular medicine · 2020Review
- The coordinate actions of calcineurin and Hog1 mediate the stress response through multiple nodes of the cell cycle network.PLoS genetics · 2020Article
- Classification and Computational Analysis ofFrontiers in genetics · 2020Article
- A balance of deubiquitinating enzymes controls cell cycle entry.Molecular biology of the cell · 2018Article
- Centromeric signaling proteins boost G1 cyclin degradation and modulate cell size in budding yeast.PLoS biology · 2018Article
- Whi7 is an unstable cell-cycle repressor of the Start transcriptional program.Nature communications · 2017Article
- A comparative study of the degradation of yeast cyclins Cln1 and Cln2.FEBS open bio · 2017Article
- Levels of Ycg1 Limit Condensin Function during the Cell Cycle.PLoS genetics · 2016Article
- Whi5 phosphorylation embedded in the G1/S network dynamically controls critical cell size and cell fate.Nature communications · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Levels of G1 cyclins fluctuate in response to environmental cues and couple mitotic signaling to cell cycle entry. The G1 cyclin Cln3 is a key regulator of cell size and cell cycle entry in budding yeast. Cln3 degradation is essential for proper cell cycle control; however, the mechanisms that control Cln3 degradation are largely unknown. Here we show that two SCF ubiquitin ligases, SCF(Cdc4) and SCF(Grr1), redundantly target Cln3 for degradation. While the F-box proteins (FBPs) Cdc4 and Grr1 were previously thought to target non-overlapping sets of substrates, we find that Cdc4 and Grr1 each bind to all 3 G1 cyclins in cell extracts, yet only Cln3 is redundantly targeted in vivo, due in part to its nuclear localization. The related cyclin Cln2 is cytoplasmic and exclusively targeted by Grr1. However, Cdc4 can interact with Cdk-phosphorylated Cln2 and target it for degradation when cytoplasmic Cdc4 localization is forced in vivo. These findings suggest that Cdc4 and Grr1 may share additional redundant targets and, consistent with this possibility, grr1Δ cdc4-1 cells demonstrate a CLN3-independent synergistic growth defect. Our findings demonstrate that structurally distinct FBPs are capable of interacting with some of the same substrates; however, in vivo specificity is achieved in part by subcellular localization. Additionally, the FBPs Cdc4 and Grr1 are partially redundant for proliferation and viability, likely sharing additional redundant substrates whose degradation is important for cell cycle progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.