ArticleEvolutionary bioinformatics online2012
Determinants of exon-level evolutionary rates in Arabidopsis species.
Article in Evolutionary bioinformatics online, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 4 citations in OpenAlex.
- Genome-Wide Identification and Expression Profiling Analysis of the Mitochondrial Calcium Uniporter Gene Family Under Abiotic Stresses inPlants (Basel, Switzerland) · 2024Article
- Comparative genomics of grass EST libraries reveals previously uncharacterized splicing events in crop plants.BMC plant biology · 2015Article
- The evolution of the coding exome of the Arabidopsis species--the influences of DNA methylation, relative exon position, and exon length.BMC evolutionary biology · 2014Article
- Three independent determinants of protein evolutionary rate.Journal of molecular evolution · 2013Review
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2 authors at 1 institution in 1 country.
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Abstract
What causes the variations in evolutionary rates is fundamental to molecular evolution. However, in plants, the causes of within-gene evolutionary rate variations remain underexplored. Here we use the principal component regression to examine the contributions of eleven exon features to the within-gene variations in nonsynonymous substitution rate (d(N)), synonymous substitution rate (d(S)), and the d(N)/d(S) ratio in Arabidopsis species. We demonstrate that exon features related to protein structural-functional constraints and mRNA splicing account for the largest proportions of within-gene variations in d(N)/d(S) and d(N). Meanwhile, for d(S), a combination of expression level, exon length, and structural-functional features explains the largest proportion of within-gene variances. Our results suggest that the determinants of within-gene variations differ from those of between-gene variations in evolutionary rates. Furthermore, the relative importance of different exon features also differs between plants and animals. Our study thus may shed a new light on the evolution of plant genes.
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