ArticleChemical physics2011
A peptide's perspective of water dynamics.
Article in Chemical physics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 59 citations in OpenAlex.
- Probing local changes to α-helical structures with 2D IR spectroscopy and isotope labeling.Biophysical journal · 2023Article
- Bottom-Up Approach to Assess the Molecular Structure of Aqueous Poly(The journal of physical chemistry. B · 2020Article
- The Amide I Spectrum of Proteins-Optimization of Transition Dipole Coupling Parameters Using Density Functional Theory Calculations.The journal of physical chemistry. B · 2020Article
- Ultrafast energy relaxation dynamics of amide I vibrations coupled with protein-bound water molecules.Nature communications · 2019Article
- Watching Proteins Wiggle: Mapping Structures with Two-Dimensional Infrared Spectroscopy.Chemical reviews · 2017Review
- Spatially Resolved Two-Dimensional Infrared Spectroscopy via Wide-Field Microscopy.ACS photonics · 2016Article
- Applications of two-dimensional infrared spectroscopy.The Analyst · 2015Review
- Hydration and vibrational dynamics of betaine (N,N,N-trimethylglycine).The Journal of chemical physics · 2015Article
- 2D IR spectroscopy of histidine: probing side-chain structure and dynamics via backbone amide vibrations.The journal of physical chemistry. B · 2014Article
- 2D IR spectroscopy reveals the role of water in the binding of channel-blocking drugs to the influenza M2 channel.The Journal of chemical physics · 2014Article
- Microscopic insights into the protein-stabilizing effect of trimethylamine N-oxide (TMAO).Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Ester carbonyl vibration as a sensitive probe of protein local electric field.Angewandte Chemie (International ed. in English) · 2014Article
- Intrinsic structural heterogeneity and long-term maturation of amyloid β peptide fibrils.ACS chemical neuroscience · 2013Article
- Three-dimensional structures by two-dimensional vibrational spectroscopy.Accounts of chemical research · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
This Perspective is focused on amide groups of peptides interacting with water. The 2D IR spectroscopy has already enabled structural aspects of the peptide backbone to be determined through its ability to measure the coupling between different amide-I modes. Here we describe why nonlinear IR is emerging as the method of choice to examine the fast components of the water dynamics near peptides and how isotopically edited peptide links can be used to probe the local water at a residue level in proteins. This type of research necessarily involves an intimate mix of theory and experiment. The description of the results is underpinned by relatively well established quantum-statistical theories that describe the important manifestations of peptide vibrational frequency fluctuations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.