ArticleJournal of immunology (Baltimore, Md. : 1950)2012
A TCR affinity threshold regulates memory CD4 T cell differentiation following vaccination.
Article in Journal of immunology (Baltimore, Md. : 1950), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Oxidized Melanoma Antigens Promote Activation and Proliferation of Cytotoxic T-Cell Subpopulations.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- Role of CD4+ T Cells in the Control of Viral Infections: Recent Advances and Open Questions.International journal of molecular sciences · 2021Review
- Memory CD4Cells · 2020Review
- Regulation of T Helper Cell Fate by TCR Signal Strength.Frontiers in immunology · 2020Review
- Early programming and late-acting checkpoints governing the development of CD4 T-cell memory.Immunology · 2018Review
- CD4 T Cell Affinity Diversity Is Equally Maintained during Acute and Chronic Infection.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- T Cells Primed by Live Mycobacteria Versus a Tuberculosis Subunit Vaccine Exhibit Distinct Functional Properties.EBioMedicine · 2018Article
- The Role of Lymphatic Niches in T Cell Differentiation.Molecules and cells · 2016Review
- Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response.Nature communications · 2016Article
- Lower Affinity T Cells are Critical Components and Active Participants of the Immune Response.Frontiers in immunology · 2015Review
- Development and Function of Protective and Pathologic Memory CD4 T Cells.Frontiers in immunology · 2015Review
- Narrowing the Gap: Preserving Repertoire Diversity Despite Clonal Selection during the CD4 T Cell Response.Frontiers in immunology · 2015Review
- Antigen signal strength during priming determines effector CD4 T cell function and antigen sensitivity during influenza virus challenge.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Frequency Patterns of T-Cell Exposed Amino Acid Motifs in Immunoglobulin Heavy Chain Peptides Presented by MHCs.Frontiers in immunology · 2014Review
- CD4 T-cell memory generation and maintenance.Critical reviews in immunology · 2014Review
- Early Decision: Effector and Effector Memory T Cell Differentiation in Chronic Infection.Current immunology reviews · 2013Article
- Monitoring the Dynamics of T Cell Clonal Diversity Using Recombinant Peptide:MHC Technology.Frontiers in immunology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Diverse Ag-specific memory TCR repertoires are essential for protection against pathogens. Subunit vaccines that combine peptide or protein Ags with TLR agonists are very potent at inducing T cell immune responses, but their capacity to elicit stable and diverse memory CD4 T cell repertoires has not been evaluated. In this study, we examined the evolution of a complex Ag-specific population during the transition from primary effectors to memory T cells after peptide or protein vaccination. Both vaccination regimens induced equally diverse effector CD4 TCR repertoires, but peptide vaccines skewed the memory CD4 TCR repertoire toward high-affinity clonotypes whereas protein vaccines maintained low-affinity clonotypes in the memory compartment. CD27-mediated signaling was essential for the maintenance of low-affinity clonotypes after protein vaccination but was not sufficient to promote their survival following peptide vaccination. The rapid culling of the TCR repertoire in peptide-immunized mice coincided with a prolonged proliferation phase during which low-affinity clonotypes disappeared despite exhibiting no sign of enhanced apoptosis. Our study reveals a novel affinity threshold for memory CD4 T cell differentiation following vaccination and suggests a role for nonapoptotic cell death in the regulation of CD4 T cell clonal selection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.