SynthesisHuman molecular genetics2012
Genome-wide meta-analysis of common variant differences between men and women.
Synthesis in Human molecular genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide association study reveals sex-specific selection signals against autosomal nucleotide variants.Journal of human genetics · 2016Pooled it
- No Evidence of Genetic Basis to Variation in Human Offspring Sex Ratio.Behavior genetics · 2026Article
- Sex-Specific Genetic Architecture and Comorbidities of Alcohol Use Behaviors.medRxiv : the preprint server for health sciences · 2025Article
- Local genetic sex differences in quantitative traits.Nature communications · 2025Article
- Is sex at birth a biological coin toss? Insights from a longitudinal and GWAS analysis.Science advances · 2025Article
- In search of the genetic variants of human sex ratio at birth: was Fisher wrong about sex ratio evolution?Proceedings. Biological sciences · 2024Article
- Increased prevalence ofHeliyon · 2024Article
- Comprehensive whole-genome analyses of the UK Biobank reveal significant sex differences in both genotype missingness and allele frequency on the X chromosome.Human molecular genetics · 2024Article
- Review
- Genetics and epigenetics of primary Sjögren syndrome: implications for future therapies.Nature reviews. Rheumatology · 2023Review
- The sexual brain, genes, and cognition: A machine-predicted brain sex score explains individual differences in cognitive intelligence and genetic influence in young children.Human brain mapping · 2022Article
- Sex-heterogeneous SNPs disproportionately influence gene expression and health.PLoS genetics · 2022Article
- Sex differences in the genetic regulation of the blood transcriptome response to glucocorticoid receptor activation.Translational psychiatry · 2021Article
- Sexual dimorphism of monocyte transcriptome in individuals with chronic low-grade inflammation.Biology of sex differences · 2021Article
- Genetic analyses identify widespread sex-differential participation bias.Nature genetics · 2021Article
- Genome-Wide Analysis of Sex Disparities in the Genetic Architecture of Lung and Colorectal Cancers.Genes · 2021Article
- Common Susceptibility Loci for Male Breast Cancer.Journal of the National Cancer Institute · 2021Article
- Evaluating human autosomal loci for sexually antagonistic viability selection in two large biobanks.Genetics · 2021Article
- The global male-bias in sex ratio at birth is sustained by the sex ratio genotypes of replacement offspring.Genetica · 2019Article
- The role of sex in the genomics of human complex traits.Nature reviews. Genetics · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
128 authors.
Funding
Abstract
The male-to-female sex ratio at birth is constant across world populations with an average of 1.06 (106 male to 100 female live births) for populations of European descent. The sex ratio is considered to be affected by numerous biological and environmental factors and to have a heritable component. The aim of this study was to investigate the presence of common allele modest effects at autosomal and chromosome X variants that could explain the observed sex ratio at birth. We conducted a large-scale genome-wide association scan (GWAS) meta-analysis across 51 studies, comprising overall 114 863 individuals (61 094 women and 53 769 men) of European ancestry and 2 623 828 common (minor allele frequency >0.05) single-nucleotide polymorphisms (SNPs). Allele frequencies were compared between men and women for directly-typed and imputed variants within each study. Forward-time simulations for unlinked, neutral, autosomal, common loci were performed under the demographic model for European populations with a fixed sex ratio and a random mating scheme to assess the probability of detecting significant allele frequency differences. We do not detect any genome-wide significant (P < 5 × 10(-8)) common SNP differences between men and women in this well-powered meta-analysis. The simulated data provided results entirely consistent with these findings. This large-scale investigation across ~115 000 individuals shows no detectable contribution from common genetic variants to the observed skew in the sex ratio. The absence of sex-specific differences is useful in guiding genetic association study design, for example when using mixed controls for sex-biased traits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.