ArticleThe Plant cell2012
Arabidopsis phytochrome a is modularly structured to integrate the multiple features that are required for a highly sensitized phytochrome.
Article in The Plant cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Both phytochrome A and phyB interact with PHYTOCHROME-INTERACTING FACTORs through an evolutionary conserved phyNature communications · 2025Article
- Structural insights into plant phytochrome A as a highly sensitized photoreceptor.Cell research · 2023Article
- The structure of Arabidopsis phytochrome A reveals topological and functional diversification among the plant photoreceptor isoforms.Nature plants · 2023Article
- From the archives: Where the light goes; flower color, chloroplast transport, and phytochrome A.The Plant cell · 2022Article
- Phytochrome Signaling Networks.Annual review of plant biology · 2021Review
- Carotenoid Biosynthesis and Plastid Development in Plants: The Role of Light.International journal of molecular sciences · 2021Review
- A de novo transcriptome analysis revealed that photomorphogenic genes are required for carotenoid synthesis in the dark-grown carrot taproot.Molecular genetics and genomics : MGG · 2020Article
- Structural insights into photoactivation and signalling in plant phytochromes.Nature plants · 2020Article
- Molecular mechanisms underlying phytochrome-controlled morphogenesis in plants.Nature communications · 2019Review
- Photoreceptor Activity Contributes to Contrasting Responses to Shade in Cardamine and Arabidopsis Seedlings.The Plant cell · 2019Article
- Mass Spectrometric Analyses Reveal a Central Role for Ubiquitylation in Remodeling the Arabidopsis Proteome during Photomorphogenesis.Molecular plant · 2017Article
- Phytochrome Signaling Is Mediated by PHYTOCHROME INTERACTING FACTOR in the Liverwort Marchantia polymorpha.The Plant cell · 2016Article
- Lysine 206 in Arabidopsis phytochrome A is the major site for ubiquitin-dependent protein degradation.Journal of biochemistry · 2016Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phytochrome is a red (R)/far-red (FR) light-sensing photoreceptor that regulates various aspects of plant development. Among the members of the phytochrome family, phytochrome A (phyA) exclusively mediates atypical phytochrome responses, such as the FR high irradiance response (FR-HIR), which is elicited under prolonged FR. A proteasome-based degradation pathway rapidly eliminates active Pfr (the FR-absorbing form of phyA) under R. To elucidate the structural basis for the phyA-specific properties, we systematically constructed 16 chimeric phytochromes in which each of four parts of the phytochrome molecule, namely, the N-terminal extension plus the Per/Arnt/Sim domain (N-PAS), the cGMP phosphodiesterase/adenyl cyclase/FhlA domain (GAF), the phytochrome domain (PHY), and the entire C-terminal half, was occupied by either the phyA or phytochrome B sequence. These phytochromes were expressed in transgenic Arabidopsis thaliana to examine their physiological activities. Consequently, the phyA N-PAS sequence was shown to be necessary and sufficient to promote nuclear accumulation under FR, whereas the phyA sequence in PHY was additionally required to exhibit FR-HIR. Furthermore, the phyA sequence in PHY alone substantially increased the light sensitivity to R. In addition, the GAF phyA sequence was important for rapid Pfr degradation. In summary, distinct structural modules, each of which confers different properties to phyA, are assembled on the phyA molecule.
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