ReviewOral and maxillofacial surgery2012
Salivary gland carcinomas.
Review in Oral and maxillofacial surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.
- Evaluation of HER2/neu expression in different types of salivary gland tumors: a systematic review and meta-analysis.Journal of medicine and life · 2022Pooled it
- Trial
- Multidisciplinary Management of Hepatic Metastasis from Submandibular Gland Adenoid Cystic Carcinoma: A Case Report and Comprehensive Literature Review.Journal of gastrointestinal cancer · 2026Review
- Clinical and Prognostic Factors of Submandibular Gland Malignancies: A SEER-Based Analysis : Analysis of Submandibular Gland Tumors.Head and neck pathology · 2026Article
- Comparison of the Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Two Groups of Patients with Benign and Malignant Salivary Gland Tumors.Iranian journal of otorhinolaryngology · 2026Article
- Neck Management in Malignant Parotid Tumors: A Retrospective Analysis of Elective Neck Dissection Indications and Outcomes.Diagnostics (Basel, Switzerland) · 2025Article
- Expression of CD73 and VEGF in salivary gland carcinomas: associations with clinicopathological characteristics in Vietnamese population.BMC cancer · 2025Article
- Clinical Utility of Whole-Genome Sequencing to Aid Histologic Diagnosis and to Direct Personalized Medicine in Salivary Gland Cancer.JCO precision oncology · 2025Article
- Trop2-Targeted Molecular Imaging in Solid Tumors: Current Advances and Future Outlook.Molecular pharmaceutics · 2024Review
- Clinical and Morphological Aspects of Aggressive Salivary Gland Mixed Tumors: A Narrative Review.Diagnostics (Basel, Switzerland) · 2024Review
- Interleukin-10 induces TNF-driven apoptosis and ROS production in salivary gland cancer cells.Heliyon · 2024Article
- Current Developments in Diagnosis of Salivary Gland Tumors: From Structure to Artificial Intelligence.Life (Basel, Switzerland) · 2024Review
- Head and neck mucoepidermoid carcinoma: does AFIP histological grading correlate with rate of nodal metastases?Oral and maxillofacial surgery · 2024Article
- Salivary gland tumors: an audit from a tertiary care centre in Northern India.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Adenoid cystic carcinoma of the parotid and submandibular glands in children and young adults: A population-based study.Pediatric blood & cancer · 2024Article
- Mucoepidermoid carcinoma of the hard palate mimicking a dental abscess: Case report.SAGE open medical case reports · 2024Article
- Article
- Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf (Canis lupus).Veterinary medicine and science · 2022Article
- Management and outcome of parotid mucoepidermoid carcinoma by histological grade: A 21-year review.Laryngoscope investigative otolaryngology · 2022Article
- Establishment of a patient-derived mucoepidermoid carcinoma cell line with theMolecular and clinical oncology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSalivary gland carcinomas are rare tumours of heterogeneous morphology that require distinctive surgical and adjuvant therapy.
methodsRelevant studies were electronically searched in PubMed and reviewed for innovative and important information.
resultsRecent insights in genetic alterations like chromosomal aberrations, expression of receptor tyrosine kinases, malfunction of tumour suppressor genes or DNA promoter methylations increased the knowledge about aetiology and pathogenesis. New histological subtypes are recognised, and a three-tiered grading system seems reasonable. Ultrasound remains the basic diagnostic imaging procedure. New developments comprise the diffusion-weighed magnetic resonance imaging, while fluorodeoxyglucose positron emission tomography/computed tomography shows good diagnostic accuracy in detecting distant metastases and local recurrence. Fine-needle aspiration cytology helps in differentiating a neoplasia from a non-neoplastic lesion while being unreliable in recognising malignancy. In contrast, additional core needle biopsy and/or intraoperative frozen section diagnosis increase the accuracy in diagnosing a malignant lesion. Conservative parotid surgery with nerve monitoring remains state-of-the-art. Free flaps or musculoaponeurotic flaps are proposed for prevention of Frey's syndrome. As parotid cancer often shows skip metastases, complete ipsilateral neck dissection (level I-V) is indicated particularly in high-grade lesions. Adjuvant radio(chemo)therapy increases local tumour control, whereas overall survival is not necessarily improved. Current results of systemic chemotherapy or targeted therapy in advanced tumour stages are disappointing.
conclusionDespite several developments, salivary gland carcinomas remain a heterogeneous group of tumours challenging both pathologists and clinicians.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.