Evidence map›Paper›PMID 22842811›Full record

ArticleJournal of endocrinological investigation2013

Association of ELMO1 gene polymorphisms with diabetic nephropathy in Chinese population.

H Y Wu, Y H Wu, Y Wang, M Chen, X Zhang, D Wang, Y Pan, L Li, D Liu, X M Dai and 1 more

Erratum issuedAbstract read
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In one paragraph

Article in Journal of endocrinological investigation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Review
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  4. Review
  5. Article
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  9. Comparative Morphological, Metabolic and Transcriptome Analyses inFrontiers in cell and developmental biology · 2022
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  13. Interaction betweenDiabetology & metabolic syndrome · 2019
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  15. Review
  16. The Susceptibility Genes in Diabetic Nephropathy.Kidney diseases (Basel, Switzerland) · 2018
    Review
  17. Article
  18. Review
  19. Review
  20. High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
4 · The record

Corrections and comments

  • Erratum issued
    Dai, M X [corrected to Dai, X M]; Wu, Y H [corrected to Wu, H Y]
5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

H Y WuDepartment of Endocrinology, Jingzhou First People's Hospital, Yangtze University, 8 Hang-kong street, Jingzhou, Hubei 434000, People's Republic of China. hongyan_wu2003@yahoo.com.cn
Y H Wu
Y Wang
M Chen
X Zhang
D Wang
Y Pan
L Li
D Liu
X M Dai
M X Dai
First People's Hospital of Jingzhou · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenetic variations in the engulfment and cell motility 1 (ELMO1) gene have recently been identified to be associated with nephropathy attributed to Type 2 diabetes mellitus (T2DM). Since T2DM-associated complications are proved to be more common among Asians than Western individuals, and Chinese people have a high incidence of diabetic nephropathy (DN), this study sought to analyze the association of ELMO1 gene polymorphisms with DN to probe into the effects of ELMO1 gene on susceptibility of DN in Chinese population.

methodsWe genotyped 6 polymorphism sites of ELMO1 gene in 200 unrelated Chinese subjects (123 T2DM with DN case subjects and 77 T2DM without DN control subjects). Genotyping was detected by a Sequenom MassARRAY genotyping system.

resultsThe strongest associations in ELMO1 gene with DN occurred at rs741301 [odds ratio (OR) 1.89; p=0.004] and rs10951509 (OR 1.76; p=0.02). Unconditional logistic regression analysis identified that the rs741301 polymorphism (presence of A allele, adjusted OR 3.27; p=0.03) and duration of T2DM (adjusted OR 1.15; p=0.04) were independent predictors for DN. The marker rs741301 located in intron 18 of ELMO1 gene was in strong linkage disequilibrium (LD) with rs11769038 (D'=0.91). Furthermore, haplotype analysis identified that haplotype 1 [CAAAGA] (OR 1.95; p=0.01), haplotype 2 [CAAAGG] (OR 0.50; p=0.01), and haplotype 9 [TGCGGG] (OR 0.17; p=0.007) of ELMO1 were significantly associated with DN.

conclusionsThis study first investigated the association of ELMO1 gene polymorphisms with DN in a Chinese population, supporting its key role as a candidate gene in the susceptibility of DN.

Indexed as

Polymorphism, Single NucleotideAdaptor Proteins, Signal TransducingAgedAllelesCase-Control StudiesChinaCohort StudiesDiabetes Mellitus, Type 2Diabetic NephropathiesFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseHumansIntronsLinkage DisequilibriumAdaptor Proteins, Signal TransducingELMO1 protein, human

Identifiers

PMID22842811
OpenAlexW180427845

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.