ArticleActa pharmacologica Sinica2012
The natural stilbenoid pinosylvin and activated neutrophils: effects on oxidative burst, protein kinase C, apoptosis and efficiency in adjuvant arthritis.
Article in Acta pharmacologica Sinica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 42 citations in OpenAlex.
- Phytochemicals and nanoformulation strategies for rheumatoid arthritis: mechanistic insights, therapeutic advances, and translational challenges.Inflammopharmacology · 2026Review
- Pinosylvin: A Multifunctional Stilbenoid with Antimicrobial, Antioxidant, and Anti-Inflammatory Potential.Current issues in molecular biology · 2025Review
- Dietary Polyphenols: Review on Chemistry/Sources, Bioavailability/Metabolism, Antioxidant Effects, and Their Role in Disease Management.Antioxidants (Basel, Switzerland) · 2024Review
- Natural Sources and Pharmacological Properties of Pinosylvin.Plants (Basel, Switzerland) · 2022Review
- Application of CRISPR/Cas System in the Metabolic Engineering of Small Molecules.Molecular biotechnology · 2021Review
- Pinosylvin exacerbates LPS-induced apoptosis via ALOX 15 upregulation in leukocytes.BMB reports · 2018Article
- Applications of CRISPR/Cas System to Bacterial Metabolic Engineering.International journal of molecular sciences · 2018Review
- Pharmacological intervention with oxidative burst in human neutrophils.Interdisciplinary toxicology · 2017Article
- A novel process for obtaining pinosylvin using combinatorial bioengineering in Escherichia coli.World journal of microbiology & biotechnology · 2016Article
- Metabolic engineering of Escherichia coli for the synthesis of the plant polyphenol pinosylvin.Applied and environmental microbiology · 2015Article
- On the molecular pharmacology of resveratrol on oxidative burst inhibition in professional phagocytes.Oxidative medicine and cellular longevity · 2014Article
- Recent biotechnological progress in enzymatic synthesis of glycosides.Journal of industrial microbiology & biotechnology · 2013Review
- The natural stilbenoid piceatannol decreases activity and accelerates apoptosis of human neutrophils: involvement of protein kinase C.Oxidative medicine and cellular longevity · 2013Article
- Study of possible mechanisms involved in the inhibitory effects of coumarin derivatives on neutrophil activity.Oxidative medicine and cellular longevity · 2013Article
- The effects of pterostilbene on neutrophil activity in experimental model of arthritis.BioMed research international · 2013Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effects of the naturally occurring stilbenoid pinosylvin on neutrophil activity in vitro and in experimental arthritis, and to examine whether protein kinase C (PKC) activation served as an assumed target of pinosylvin action.
methodsFresh human blood neutrophils were isolated. The oxidative burst of neutrophils was evaluated on the basis of enhanced chemiluminescence. Neutrophil viability was evaluated with flow cytometry, and PKC phosphorylation was assessed by Western blotting analysis. Adjuvant arthritis was induced in Lewis rats with heat-killed Mycobacterium butyricum, and the animals were administered with pinosylvin (30 mg/kg, po) daily for 21 d after arthritis induction.
resultsIn isolated human neutrophils, pinosylvin (10 and 100 μmol/L) significantly decreased the formation of oxidants, both extra- and intracellularly, and effectively inhibited PKC activation stimulated by phorbol myristate acetate (0.05 μmol/L). The inhibition was not due to neutrophil damage or increased apoptosis. In arthritic rats, the number of neutrophils in blood was dramatically increased, and whole blood chemiluminescence (spontaneous and PMA-stimulated) was markedly enhanced. Pinosylvin administration decreased the number of neutrophils (from 69 671 ± 5588/μL to 51 293 ± 3947/μL, P=0.0198) and significantly reduced the amount of reactive oxygen species in blood.
conclusionPinosylvin is an effective inhibitor of neutrophil activity, and is potentially useful as a complementary medicine in states associated with persistent inflammation.
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