ArticleNature neuroscience2012
Paradoxical contribution of SK3 and GIRK channels to the activation of mouse vomeronasal organ.
Article in Nature neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 53 citations in OpenAlex.
- Dopamine modulation of aggression.Psychopharmacology · 2026Review
- CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Molecular, Cellular, and Developmental Organization of the Mouse Vomeronasal organ at Single Cell Resolution.bioRxiv : the preprint server for biology · 2024Article
- Sex-dependent control of pheromones on social organization within groups of wild house mice.Current biology : CB · 2023Article
- Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation.The Journal of general physiology · 2023Article
- Two Preputial Gland-Secreted Pheromones Evoke Sexually Dimorphic Neural Pathways in the Mouse Vomeronasal System.Frontiers in cellular neuroscience · 2019Article
- Signal Detection and Coding in the Accessory Olfactory System.Chemical senses · 2018Review
- G protein γ subunit Gγ13 is essential for olfactory function and aggressive behavior in mice.Neuroreport · 2018Article
- CaThe Journal of biological chemistry · 2018Article
- Loss of Glis3 causes dysregulation of retrotransposon silencing and germ cell demise in fetal mouse testis.Scientific reports · 2018Article
- Type 3 inositol 1,4,5-trisphosphate receptor is dispensable for sensory activation of the mammalian vomeronasal organ.Scientific reports · 2017Article
- Article
- Elevated Cytosolic Cl- Concentrations in Dendritic Knobs of Mouse Vomeronasal Sensory Neurons.Chemical senses · 2016Article
- Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Molecular and neural control of sexually dimorphic social behaviors.Current opinion in neurobiology · 2016Review
- Genetic dissection of neural circuits underlying sexually dimorphic social behaviours.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Intracellular chloride concentration of the mouse vomeronasal neuron.BMC neuroscience · 2015Article
- Mammalian pheromones: emerging properties and mechanisms of detection.Current opinion in neurobiology · 2015Review
- Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
The vomeronasal organ (VNO) is essential for intraspecies communication in many terrestrial vertebrates. The ionic mechanisms of VNO activation remain unclear. We found that the calcium-activated potassium channel SK3 and the G protein-activated potassium channel GIRK are part of an independent pathway for VNO activation. In slice preparations, the potassium channels attenuated inward currents carried by TRPC2 and calcium-activated chloride channels (CACCs). In intact tissue preparations, paradoxically, the potassium channels enhanced urine-evoked inward currents. This discrepancy resulted from the loss of a high concentration of lumenal potassium, which enabled the influx of potassium ions to depolarize the VNO neurons in vivo. Both Sk3 (also known as Kcnn3) and Girk1 (also known as Kcnj3) homozygous null mice showed deficits in mating and aggressive behaviors, and the deficiencies in Sk3(-/-) mice were exacerbated by Trpc2 knockout. Our results suggest that VNO activation is mediated by TRPC2, CACCs and two potassium channels, all of which contributed to the in vivo depolarization of VNO neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.