SynthesisContemporary clinical trials2012
Informing the dosing of interventions in randomized trials.
Synthesis in Contemporary clinical trials, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- A systematic review of physical activity-based interventions to prevent or reduce chronic post-surgical pain.Pain medicine (Malden, Mass.) · 2026Pooled it
- Effects of active breaks on attention and executive function in children and adolescents: A meta-analysis.European journal of pediatrics · 2026Pooled it
- Does Mandala Art Improve Psychological Well-Being in Patients? A Systematic Review.Journal of integrative and complementary medicine · 2024Pooled it
- The dose of behavioral interventions to prevent and treat childhood obesity: a systematic review and meta-regression.The international journal of behavioral nutrition and physical activity · 2017Pooled it
- Psychosocial interventions for men with prostate cancer.The Cochrane database of systematic reviews · 2013Pooled it
- Lost and not found: randomized controlled trial of cognitive behavioral therapy for weight-loss in patients with chronic kidney disease.Journal of behavioral medicine · 2025Trial
- Implementation of Community Health Worker Support for Tobacco Cessation: A Mixed-Methods Study.Psychiatric services (Washington, D.C.) · 2025Trial
- Implementation Fidelity and Theory-Informed Dose Effects of a Teen Pregnancy Prevention Program for Native American Youth.Prevention science : the official journal of the Society for Prevention Research · 2023Trial
- A pilot clinical trial of a self-management intervention in patients with a left ventricular assist device.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2022Trial
- Promoting Higher Quality Teacher-Child Relationships: The INSIGHTS Intervention in Rural Schools.International journal of environmental research and public health · 2020Trial
- Smartphone-Delivered Progressive Muscle Relaxation for the Treatment of Migraine in Primary Care: A Randomized Controlled Trial.Headache · 2020Trial
- The BestFIT trial: A SMART approach to developing individualized weight loss treatments.Contemporary clinical trials · 2016Trial
- Linking Adherence to Effectiveness in Family-Based Adolescent ADHD Academic Training and Medication Decision-Making Protocols.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Trial
- The Impact of Social Support on Treatment Participation and Completion in a Disability Prevention Intervention for Older Adults.Journal of aging and healthTrial
- Article
- Fidelity Assessment of the Multiple Family Group Intervention for Disruptive Behavioral Disorders Among Children and Adolescents in Uganda.Evidence-based practice in child and adolescent mental health · 2025Article
- Qualitative Exploration of a Tele-exercise Program to Inform the Design of Adaptive Intervention Strategies for Adults With Multiple Sclerosis.Archives of rehabilitation research and clinical translation · 2025Article
- The role of art knowledge training on aesthetic judgements and executive functions.Royal Society open science · 2025Article
- Hyped-up or meditate: A scoping review of mindfulness-based group interventions for adolescents with attention deficit hyperactivity disorder.Clinical child psychology and psychiatry · 2024Article
- Implementation of Community Health Worker Support for Tobacco Cessation: A Mixed-Methods Study.medRxiv : the preprint server for health sciences · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Dosing is potentially the most important decision that must be made when building or refining behavioral interventions. In this paper, we propose standardized terminology and reporting of dosing information, which would inform intervention development, refinement for dissemination, and systematic reviews of dose-response relationships. Dosing of interventions may be characterized by duration, frequency, and amount. To illustrate the value of operationalizing these three parameters to evaluate dose-response relationships, 31 published reports of behavioral interventions to increase adherence to antiretroviral therapy (ART) were reviewed. The ART literature was characterized by under-reporting of dosing parameters, heterogeneity in dosing schedules, and heterogeneity in type of control group, which complicate analysis of dose-response relationships in systematic review and determination of the optimal dose for intervention dissemination. Improved reporting of the three dosing parameters and comparison of intended to actual delivery can inform the identification of the most effective intervention doses and the efficient implementation of efficacious interventions in clinical practice.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.