ReviewProgress in neurobiology2012
Neurobiological studies of fatigue.
Review in Progress in neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.
- Neural Mechanisms Underlying Breast Cancer Related Fatigue: A Systematic Review of Neuroimaging Studies.Frontiers in neuroscience · 2021Pooled it
- Shortened Sleep Duration Causes Sleepiness, Inattention, and Oppositionality in Adolescents With Attention-Deficit/Hyperactivity Disorder: Findings From a Crossover Sleep Restriction/Extension Study.Journal of the American Academy of Child and Adolescent Psychiatry · 2019Trial
- Neural correlates of perceived physical and mental fatigability in older adults: A pilot study.Experimental gerontology · 2019Trial
- Neural and computational mechanisms of effort under the pressure of a deadline.Nature communications · 2026Article
- A mouse model to study persistent fatigue.Research square · 2026Article
- Fatigue in major depression is linked to depression severity, not sleep duration or anterior cingulate cortex neurochemistry.Journal of affective disorders · 2026Article
- Sleep fragmentation intensifies sleep architecture disruption and fatigue after traumatic brain injury.Experimental neurology · 2026Article
- Article
- Bibliometric and visual analysis of overlooked fatigue in kidney transplantation: a narrative review.Annals of medicine and surgery (2012) · 2025Review
- Mental fatigue and cognitive functioning in patients presenting with non-enhancing gliomas.Acta neurochirurgica · 2025Article
- Cerebral microstructural alterations in Post-COVID-condition are related to cognitive impairment, olfactory dysfunction and fatigue.Nature communications · 2024Article
- Fatigue and perceived energy in a sample of older adults over 10 years: A resting state functional connectivity study of neural correlates.Experimental gerontology · 2024Article
- Exploring cariprazine as a treatment option for varied depression symptom clusters.Frontiers in psychiatry · 2024Review
- Altered motivation states for physical activity and 'appetite' for movement as compensatory mechanisms limiting the efficacy of exercise training for weight loss.Frontiers in psychology · 2023Article
- Epileptic seizure clustering and accumulation at transition from activity to rest in GAERS rats.Frontiers in neurology · 2023Article
- Tonic activity in lateral habenula neurons acts as a neutral valence brake on reward-seeking behavior.Current biology : CB · 2022Article
- Computer vision-based approach to detect fatigue driving and face mask for edge computing device.Heliyon · 2022Article
- A comprehensive review of approaches to detect fatigue using machine learning techniques.Chronic diseases and translational medicine · 2022Review
- KangPiLao decoction modulates cognitive and emotional disorders in rats with central fatigue through the GABA/Glu pathway.Frontiers in pharmacology · 2022Article
- Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models.Neurobiology of stress · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Fatigue is a symptom associated with many disorders, is especially common in women and in older adults, and can have a huge negative influence on quality of life. Although most past research on fatigue uses human subjects instead of animal models, the use of appropriate animal models has recently begun to advance our understanding of the neurobiology of fatigue. In this review, results from animal models using immunological, developmental, or physical approaches to study fatigue are described and compared. Common across these animal models is that fatigue arises when a stimulus induces activation of microglia and/or increased cytokines and chemokines in the brain. Neurobiological studies implicate structures in the ascending arousal system, sleep executive control areas, and areas important in reward. In addition, the suprachiasmatic nucleus clearly plays an important role in homeostatic regulation of the neural network mediating fatigue. This nucleus responds to cytokines, shows decreased amplitude firing rate output in models of fatigue, and responds to exercise, one of our few treatments for fatigue. This is a young field but very important as the symptom of fatigue is common across many disorders and we do not have effective treatments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.