Evidence map›Paper›PMID 22841347›Full record

ReviewCurrent opinion in immunology2012

The role of induced pluripotent stem cells in research and therapy of primary immunodeficiencies.

Katja G Weinacht, Patrick M Brauer, Kerstin Felgentreff, Alex Devine, Andrew R Gennery, Silvia Giliani, Waleed Al-Herz, Axel Schambach, Juan Carlos Zúñiga-Pflücker, Luigi D Notarangelo

Abstract readReview
In one paragraph

Review in Current opinion in immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. In Vitro Model Systems to Study Human T Cell Development.Methods in molecular biology (Clifton, N.J.) · 2023
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Katja G WeinachtDivision of Hematology/Oncology, Children's Hospital Boston, Boston, USA.
Patrick M Brauer
Kerstin Felgentreff
Alex Devine
Andrew R Gennery
Silvia Giliani
Waleed Al-Herz
Axel Schambach
Juan Carlos Zúñiga-Pflücker
Luigi D Notarangelo

Funding

Modeling and correcting human SCID using patient-derived iPS cellsR01AI100887 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI MANIS, JOHN P · 2012 to 2020
$4.5M
The Initiation of B-Cell SignalingZ01AI000898 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI PIERCE, SUSAN · 2001 to 2008
$1.8M
In vitro differentiation of RAG1-mutated iPS cells and correction by meganucleaseR21AI089810 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI NOTARANGELO, LUIGI DANIELE · 2010 to 2011
$444k
Intramural NIH HHS Z01 AI000898NIAID NIH HHS 1R01AI100887-001NIAID NIH HHS 5R21AI0898-02NIAID NIH HHS R01 AI100887NIAID NIH HHS R21 AI089810
6 · The paper itself

Abstract

The advent of reprogramming technology has greatly advanced the field of stem cell biology and nurtured our hope to create patient specific renewable stem cell sources. While the number of reports of disease specific induced pluripotent stem cells is continuously rising, the field becomes increasingly more aware that induced pluripotent stem cells are not as similar to embryonic stem cells as initially assumed. Our state of the art understanding of human induced pluripotent stem cells, their capacity, their limitations and their promise as it pertains to the study and treatment of primary immunodeficiencies, is the content of this review.

Indexed as

AnimalsCell DifferentiationCell TransplantationDisease Models, AnimalHumansImmunologic Deficiency SyndromesPluripotent Stem CellsRegenerative Medicine

Identifiers

PMID22841347
PMCPMC3478496

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.