ReviewNeuron2012
Development and plasticity of the primary visual cortex.
Review in Neuron, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 407 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
407 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Binocular versus standard occlusion or blurring treatment for unilateral amblyopia in children aged three to eight years.The Cochrane database of systematic reviews · 2022Pooled it
- Eye-specific drive and binocular suppression in mouse visual cortex during critical period development.bioRxiv : the preprint server for biology · 2026Article
- Mismatch negativity matures in adolescence and without sensitivity to microglial depletion.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- PSD-95 drives binocular vision maturation critical for predation.bioRxiv : the preprint server for biology · 2026Article
- Trends in neuroprosthetic technologies to restore sensations.Biomedical engineering letters · 2026Review
- Dual-brain fusion: Bidirectional empowerment between human brain and brain-inspired systems.Fundamental research · 2026Review
- Lhx2 Regulates Distinct Dendritic Architecture of Pyramidal Neurons across Primary Sensory Areas.eNeuro · 2026Article
- Synaptic Development of Fine Spatial Scale Organization of Neuronal Orientation Tuning in Mouse Primary Visual Cortex.bioRxiv : the preprint server for biology · 2026Article
- Differentiation of cortical areas: effects of free energy minimization with broken symmetry.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Unpredictable caregiving is associated with disrupted neurophysiological measures of attention and autonomic function in three-month-old infants.Developmental cognitive neuroscience · 2026Article
- δ-catenin controls layer-specific transcriptional maturation of astrocytes via Zbtb20.bioRxiv : the preprint server for biology · 2026Article
- Visually guided voluntary actions boost short-term ocular dominance plasticity.Scientific reports · 2026Article
- Binocular Afferent Synchrony During Development and in Amblyopia: Evidence From Dominance-Referenced Multichannel Visual Evoked Potentials.Investigative ophthalmology & visual science · 2026Article
- Deep-learning-assisted simulation of a cortical circuit: integrating anatomy, physiology and function.bioRxiv : the preprint server for biology · 2026Article
- Article
- Shared genetic architecture of cortical morphology and psychiatric disorders: insights from a cross-trait analyses across 180 cortical regions.medRxiv : the preprint server for health sciences · 2026Article
- Mean Apparent Propagator MRI: A Potential Imaging Biomarker of Brain Microstructural Alterations in Basic-Type Intermittent Exotropia.Investigative ophthalmology & visual science · 2026Article
- Population-level encoding of task information is stronger in the adolescent compared to adult frontal cortex.Developmental cognitive neuroscience · 2026Article
- Interrelations between dopaminergic-, gabaergic- and glutamatergic neurotransmitters in antipsychotic-naïve psychosis patients and the association to initial treatment response.Molecular psychiatry · 2026Article
- Growth-adaptive spring electronics for long-term, same-neuron mapping in the developing rat brain.bioRxiv : the preprint server for biology · 2026Article
347 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Hubel and Wiesel began the modern study of development and plasticity of primary visual cortex (V1), discovering response properties of cortical neurons that distinguished them from their inputs and that were arranged in a functional architecture. Their findings revealed an early innate period of development and a later critical period of dramatic experience-dependent plasticity. Recent studies have used rodents to benefit from biochemistry and genetics. The roles of spontaneous neural activity and molecular signaling in innate, experience-independent development have been clarified, as have the later roles of visual experience. Plasticity produced by monocular visual deprivation (MD) has been dissected into stages governed by distinct signaling mechanisms, some of whose molecular players are known. Many crucial questions remain, but new tools for perturbing cortical cells and measuring plasticity at the level of changes in connections among identified neurons now exist. The future for the study of V1 to illuminate cortical development and plasticity is bright.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.