ReviewNeuron2012
From functional architecture to functional connectomics.
Review in Neuron, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Monosynaptic connections link functionally similar regions in human cortex.bioRxiv : the preprint server for biology · 2026Article
- Deep learning-driven characterization of single cell tuning in primate visual area V4 supports topological organization.bioRxiv : the preprint server for biology · 2025Article
- Article
- Article
- Prediction of future input explains lateral connectivity in primary visual cortex.Current biology : CB · 2025Article
- Functional connectomics reveals general wiring rule in mouse visual cortex.bioRxiv : the preprint server for biology · 2024Article
- Correlated variability and its attentional modulation depend on anatomical connectivity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Statistical perspective on functional and causal neural connectomics: The Time-Aware PC algorithm.PLoS computational biology · 2022Article
- In vivo extracellular recordings of thalamic and cortical visual responses reveal V1 connectivity rules.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Connectomic features underlying diverse synaptic connection strengths and subcellular computation.Current biology : CB · 2022Article
- Statistical Perspective on Functional and Causal Neural Connectomics: A Comparative Study.Frontiers in systems neuroscience · 2022Article
- Mortality Prediction of Patients With Cardiovascular Disease Using Medical Claims Data Under Artificial Intelligence Architectures: Validation Study.JMIR medical informatics · 2021Article
- Unexpected hubness: a proof-of-concept study of the human connectome using pagerank centrality and implications for intracerebral neurosurgery.Journal of neuro-oncology · 2021Article
- Origins of Functional Organization in the Visual Cortex.Frontiers in systems neuroscience · 2020Review
- Aberration-free multi-plane imaging of neural activity from the mammalian brain using a fast-switching liquid crystal spatial light modulator.Biomedical optics express · 2019Article
- Functional emergence of a column-like architecture in layer 5 of mouse somatosensory cortex in vivo.The journal of physiological sciences : JPS · 2019Article
- Large-scale neuroanatomy using LASSO: Loop-based Automated Serial Sectioning Operation.PloS one · 2018Article
- Neuronal cell-type classification: challenges, opportunities and the path forward.Nature reviews. Neuroscience · 2017Review
- Weighing the Evidence in Peters' Rule: Does Neuronal Morphology Predict Connectivity?Trends in neurosciences · 2017Review
- Wiring visual systems: common and divergent mechanisms and principles.Current opinion in neurobiology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
"Receptive Fields, Binocular Interaction and Functional Architecture in the Cat's Visual Cortex" by Hubel and Wiesel (1962) reported several important discoveries: orientation columns, the distinct structures of simple and complex receptive fields, and binocular integration. But perhaps the paper's greatest influence came from the concept of functional architecture (the complex relationship between in vivo physiology and the spatial arrangement of neurons) and several models of functionally specific connectivity. They thus identified two distinct concepts, topographic specificity and functional specificity, which together with cell-type specificity constitute the major determinants of nonrandom cortical connectivity. Orientation columns are iconic examples of topographic specificity, whereby axons within a column connect with cells of a single orientation preference. Hubel and Wiesel also saw the need for functional specificity at a finer scale in their model of thalamic inputs to simple cells, verified in the 1990s. The difficult but potentially more important question of functional specificity between cortical neurons is only now becoming tractable with new experimental techniques.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.