Evidence map›Paper›PMID 22841304›Full record

ArticleNeuron2012

Have you heard? Viral-mediated gene therapy restores hearing.

Donna M Martin, Yehoash Raphael

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Sound strategies for hearing restoration.Science (New York, N.Y.) · 2014
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Donna M MartinDepartment of Pediatrics, The University of Michigan, Ann Arbor, MI 48109, USA.
Yehoash Raphael
University of Michigan · US

Funding

Scientific Synergy CoreP30DC005188 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DOLAN, DAVID FRANCIS · 2002 to 2016
$10.3M
Developmental Mechanisms of the Chromodomain Gene Chd7R01DC009410 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARTIN, DONNA M. · 2009 to 2018
$3.7M
SCAR FORMATION IN DAMAGED AND REGENERATING COCHLEAER01DC001634 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAPHAEL, YEHOASH · 1993 to 2009
$2.4M
Cochlear Implants in Reinnervated EarsR01DC010412 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAPHAEL, YEHOASH · 2010 to 2014
$2.2M
NIDCD NIH HHS P30 DC005188NIDCD NIH HHS R01 DC001634NIDCD NIH HHS R01 DC009410NIDCD NIH HHS R01 DC010412
6 · The paper itself

Abstract

Genetic loss of VGLUT3 in cochlear inner hair cells results in profound deafness. In this issue of Neuron, Akil et al. (2012) show that AAV-mediated introduction of wild-type VGLUT3 in the genetically deaf mouse cochlea results in significantly improved hearing.

Indexed as

Amino Acid Transport Systems, AcidicAnimalsDeafnessEvoked Potentials, Auditory, Brain StemGenetic TherapyReflex, StartleAmino Acid Transport Systems, AcidicSlc17a8 protein, mouse

Identifiers

PMID22841304
PMCPMC4502432
OpenAlexW2052865278

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.