ArticleCell2012
Evolutionary history and adaptation from high-coverage whole-genome sequences of diverse African hunter-gatherers.
Article in Cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers.
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Who cites it
142 citing papers in PubMed, 352 citations in OpenAlex.
- Genomic evidence for shared common ancestry of East African hunting-gathering populations and insights into local adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2019Trial
- Long-term isolation and archaic introgression shape functional genetic variation in Near Oceania.Science (New York, N.Y.) · 2026Article
- Recovering signatures of archaic introgression using ancestral recombination graphs.bioRxiv : the preprint server for biology · 2026Article
- Accounting for gene flow from unsampled ghost populations while estimating evolutionary history.G3 (Bethesda, Md.) · 2025Article
- Global impact of micronutrients in modern human evolution.American journal of human genetics · 2025Article
- CADET: Enhanced transcriptome-wide association analyses in admixed samples using eQTL summary data.American journal of human genetics · 2025Article
- Dentition of the Mugharet El'Aliya Fossil Human Maxilla, Morocco.American journal of biological anthropology · 2025Article
- Genetic history and biological adaptive landscape of the Tujia people inferred from shared haplotypes and alleles.Human genomics · 2024Article
- Ancestral Origins and Admixture History of Kazakhs.Molecular biology and evolution · 2024Article
- Spatial and temporal diversity of positive selection on shared haplotypes at the PSCA locus among worldwide human populations.Heredity · 2023Article
- Human subsistence and signatures of selection on chemosensory genes.Communications biology · 2023Article
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- Evolutionary Genetics and Admixture in African Populations.Genome biology and evolution · 2023Review
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- Article
- Revisiting the Evolutionary History of Pigs via De Novo Mutation Rate Estimation in A Three-generation Pedigree.Genomics, proteomics & bioinformatics · 2022Article
- Is there still evolution in the human population?Biologia futura · 2022Review
- Merging morphological and genetic evidence to assess hybridization in Western Eurasian late Pleistocene hominins.Nature ecology & evolution · 2022Article
- Genetic Diversity and Selective Signature in Dabieshan Cattle Revealed by Whole-Genome Resequencing.Biology · 2022Article
- Article
82 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 4 countries.
Funding
Abstract
To reconstruct modern human evolutionary history and identify loci that have shaped hunter-gatherer adaptation, we sequenced the whole genomes of five individuals in each of three different hunter-gatherer populations at > 60× coverage: Pygmies from Cameroon and Khoesan-speaking Hadza and Sandawe from Tanzania. We identify 13.4 million variants, substantially increasing the set of known human variation. We found evidence of archaic introgression in all three populations, and the distribution of time to most recent common ancestors from these regions is similar to that observed for introgressed regions in Europeans. Additionally, we identify numerous loci that harbor signatures of local adaptation, including genes involved in immunity, metabolism, olfactory and taste perception, reproduction, and wound healing. Within the Pygmy population, we identify multiple highly differentiated loci that play a role in growth and anterior pituitary function and are associated with height.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.