ArticleAmerican journal of obstetrics and gynecology2012
Tissue factor-dependent thrombin generation across pregnancy.
Article in American journal of obstetrics and gynecology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 62 citations in OpenAlex.
- Fibrinogen Deficiency and Dysfunction in Postpartum Hemorrhage: Evidence, Thresholds, and Management Across Resource Settings.Journal of clinical medicine · 2026Review
- Postoperative venous thromboembolism following cesarean delivery: prevalence, pathophysiology, diagnosis, treatment, and prevention.American journal of obstetrics and gynecology · 2026Review
- A Serious Headache: Lessons Learned from the Management of Pregnancy-Associated Venous Sinus Thrombosis in a Region with Limited Abortion Access.Neurocritical care · 2025Article
- Altered clot structure in pregnant women who will develop postpartum hemorrhage.Research and practice in thrombosis and haemostasis · 2025Article
- Hemostasis in Pre-Eclamptic Women and Their Offspring: Current Knowledge and Hemostasis Assessment with Viscoelastic Tests.Diagnostics (Basel, Switzerland) · 2024Review
- Risk stratification for pregnancy-associated venous thromboembolism: Potential role for global coagulation assays.Obstetric medicine · 2022Review
- Placental Maternal Vascular Malperfusion is Associated with Prepregnancy and Early Pregnancy Maternal Cardiovascular and Thrombotic Profiles.Reproductive medicine (Basel, Switzerland) · 2022Article
- Cerebrovascular disease in pregnancy and puerperium: perspectives from neuroradiologists.Quantitative imaging in medicine and surgery · 2021Review
- Anatomical and physiological alterations of pregnancy.Journal of pharmacokinetics and pharmacodynamics · 2020Review
- Impaired platelet-dependent thrombin generation associated with thrombocytopenia is improved by prothrombin complex concentrates in vitro.Research and practice in thrombosis and haemostasis · 2020Article
- Low molecular weight heparins use in pregnancy: a practice survey from Greece and a review of the literature.Thrombosis journal · 2019Article
- No effect of tranexamic acid on platelet function and thrombin generation (ETAPlaT) in postpartum haemorrhage: a randomised placebo-controlled trial.Wellcome open research · 2019Article
- The pattern and magnitude of "in vivo thrombin generation" differ in women with preeclampsia and in those with SGA fetuses without preeclampsia.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2018Article
- Thrombin generation test as a marker for high risk venous thrombosis pregnancies.Journal of thrombosis and thrombolysis · 2018Article
- Statistical analysis plan for the WOMAN-ETAPlaT study: Effect of tranexamic acid on platelet function and thrombin generation.Wellcome open research · 2016Article
- Thrombophilia and Pregnancy Complications.International journal of molecular sciences · 2015Review
- Global assays of hemostasis in the diagnostics of hypercoagulation and evaluation of thrombosis risk.Thrombosis journal · 2015Article
- Changes in thrombin generation and D-dimer concentrations in women injecting enoxaparin during pregnancy and the puerperium.BMC pregnancy and childbirth · 2014Article
- Causality relationships between coagulation factors in type 2 diabetes mellitus: path analysis approach.Medical journal of the Islamic Republic of Iran · 2014Article
- Modeling thrombin generation: plasma composition based approach.Journal of thrombosis and thrombolysis · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveNormal pregnancy results in a prothrombotic state. Studies that have investigated the capacity of pregnant women to generate thrombin are limited. Our aim was to evaluate thrombin generation longitudinally from the preconception period, through pregnancy, and after pregnancy. STUDY
designWe evaluated young, healthy nulligravid women (n = 20) at 4 time points and compared the data with 10 control women at 2 time points. Coagulation was initiated with tissue factor in contact pathway inhibited plasma, and thrombin generation was determined in the presence of a fluorogenic substrate.
resultsThe maximum level and rate of thrombin generation increased during pregnancy; the highest level and rate occurred in late pregnancy compared with prepregnancy (P < .001). Subsequently, thrombin generation decreased in the postpregnancy samples that included maximum level, rate, and area under the curve (P < .001).
conclusionOur data provide evidence for an increase in tissue factor-dependent thrombin generation with pregnancy progression, followed by a return to prepregnancy thrombin levels.
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Registered trials
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