ArticleEarly human development2012
Very low birth weight neonates who survive early-onset sepsis do not have an increased risk of developing late-onset sepsis.
Article in Early human development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- Predictors of gentamicin therapy failure in neonates with sepsis.Pharmacology research & perspectives · 2024Article
- Patterns of Infections among Extremely Preterm Infants.Journal of clinical medicine · 2023Article
- Five Year Follow Up of Extremely Low Gestational Age Infants after Timely or Delayed Administration of Routine Vaccinations.Vaccines · 2021Article
- Association between biofilm formation, structure and antibiotic resistance inInfection and drug resistance · 2019Article
- Sepsis-Induced Immunosuppression in Neonates.Frontiers in pediatrics · 2018Review
- Impact of Early-Life Exposures to Infections, Antibiotics, and Vaccines on Perinatal and Long-term Health and Disease.Frontiers in immunology · 2017Review
- Early-onset neonatal sepsis.Clinical microbiology reviews · 2014Review
- Review
- Early sepsis does not increase the risk of late sepsis in very low birth weight neonates.The Journal of pediatrics · 2013Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundVery low birth weight neonates (≤ 1500 g, VLBWs) have a high rate of infection and distinct baseline immune function compared with more mature populations. In critically ill children and adults, sepsis increases subsequent infection risk. It is unknown whether sepsis modifies the risk of subsequent infection in VLBWs.
methodsWe conducted a retrospective cohort study of VLBWs≤32weeks of gestation at birth cared for in 312 neonatal intensive care units in the United States from 1997 to 2011 (n=103,376). Early-onset sepsis (EOS, culture-positive only) and late-onset sepsis (LOS, culture-positive or clinical) cases were identified. Cox proportional hazard models were used to control for clinical variables between neonates with and without EOS to determine if EOS modified risk of LOS, necrotizing enterocolitis (NEC), or death.
resultsLOS occurred in 12,112/102,317 (11.8%) neonates without EOS and in 133/1059 (12.6%) of those with EOS. After adjustment for clinical variables, the risk of LOS was not different between neonates with or without a history of EOS (hazard ratio [HR]=0.92; 95% confidence interval [CI] 0.74, 1.16). EOS increased the risk of 120-day mortality (HR=1.78; 95% CI 1.49, 2.13).
conclusionsIn contrast to findings in children and adults, EOS was not associated with an increased risk of LOS in this cohort. Age-specific investigations are needed to determine if post-sepsis immunologic alterations are present.
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