ArticleCell reports2012
Genomic imprinting absent in Drosophila melanogaster adult females.
Article in Cell reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- The impact of P-element-induced hybrid dysgenesis on the male germline in Drosophila simulans.Genetics · 2026Article
- Fitness consequences of sex chromosome aneuploidy in Drosophila melanogaster.PLoS genetics · 2025Article
- cis- and trans-regulatory contributions to a hierarchy of factors influencing gene expression variation.Communications biology · 2024Article
- Cis-regulatory Variation in Relation to Sex and Sexual Dimorphism in Drosophila melanogaster.Genome biology and evolution · 2024Article
- Pervasive tissue-, genetic background-, and allele-specific gene expression effects in Drosophila melanogaster.PLoS genetics · 2024Article
- Sex-specific estimation of cis and trans regulation of gene expression in heads and gonads of Drosophila melanogaster.G3 (Bethesda, Md.) · 2023Article
- Genetic Targeting of dSAMTOR, A Negative dTORC1 Regulator, duringInternational journal of molecular sciences · 2023Article
- Nuclear genetic background influences the phenotype of the Drosophila tko25t mitochondrial protein-synthesis mutant.G3 (Bethesda, Md.) · 2023Article
- Differential Grainy head binding correlates with variation in chromatin structure and gene expression in Drosophila melanogaster.BMC genomics · 2022Article
- Males That Silence Their Father's Genes: Genomic Imprinting of a Complete Haploid Genome.Molecular biology and evolution · 2021Article
- Genomics Analysis of L-DOPA Exposure inG3 (Bethesda, Md.) · 2019Article
- Ancestral diet transgenerationally influences offspring in a parent-of-origin and sex-specific manner.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Spatially varying cis-regulatory divergence in Drosophila embryos elucidates cis-regulatory logic.PLoS genetics · 2018Article
- Gene Regulatory Variation inGenetics · 2018Article
- Hierarchical analysis of RNA-seq reads improves the accuracy of allele-specific expression.Bioinformatics (Oxford, England) · 2018Article
- Do social insects support Haig's kin theory for the evolution of genomic imprinting?Epigenetics · 2017Review
- A Generalized Linear Model for DecomposingG3 (Bethesda, Md.) · 2017Article
- Article
- Paramutation and related phenomena in diverse species.Nature reviews. Genetics · 2017Review
- Allele-Specific Transcriptome and Methylome Analysis Reveals Stable Inheritance and Cis-Regulation of DNA Methylation in Nasonia.PLoS biology · 2016Article
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Authors and funding
5 authors.
Funding
Abstract
Genomic imprinting occurs when expression of an allele differs based on the sex of the parent that transmitted the allele. In D. melanogaster, imprinting can occur, but its impact on allelic expression genome-wide is unclear. Here, we search for imprinted genes in D. melanogaster using RNA-seq to compare allele-specific expression between pools of 7- to 10-day-old adult female progeny from reciprocal crosses. We identified 119 genes with allelic expression consistent with imprinting, and these genes showed significant clustering within the genome. Surprisingly, additional analysis of several of these genes showed that either genomic heterogeneity or high levels of intrinsic noise caused imprinting-like allelic expression. Consequently, our data provide no convincing evidence of imprinting for D. melanogaster genes in their native genomic context. Elucidating sources of false-positive signals for imprinting in allele-specific RNA-seq data, as done here, is critical given the growing popularity of this method for identifying imprinted genes.
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